A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes

Kirsty Millar; J Brown; J C Maule; Y Shibasaki; S Christie; D Lawson; Susan Anderson; J C Wilson-Annan; Rebecca Devon; D M St Clair; Douglas Blackwood; Walter Muir; D J Porteous

A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes

Kirsty Millar, J Brown, J C Maule, Y Shibasaki, S Christie, D Lawson, Susan Anderson, J C Wilson-Annan, Rebecca Devon, D M St Clair, Douglas Blackwood, Walter Muir, D J Porteous

Research output: Contribution to journal › Article › peer-review

Abstract

A balanced t(1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related mental illness in a single large Scottish pedigree. We have constructed a long-range restriction map covering at least 3 Mb of the chromosome 11 breakpoint region and conducted searches for genes whose expression could be altered by the translocation, resulting in schizophrenia. Novel transcribed sequences of unknown function clustered around putative CpG islands, located approximately 500 kb and 700 kb above the breakpoint, represent the only evidence to date for expressed genes within the mapped region.

Original language	English
Pages (from-to)	175-81
Number of pages	7
Journal	Psychiatric Genetics
Volume	8
Issue number	3
Publication status	Published - 1998

Keywords / Materials (for Non-textual outputs)

Cells, Cultured
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 11
Cosmids
CpG Islands
Expressed Sequence Tags
Gene Library
Genetic Predisposition to Disease
Humans
In Situ Hybridization, Fluorescence
Pedigree
Polymerase Chain Reaction
Restriction Mapping
Schizophrenia
Scotland
Transcription, Genetic
Translocation, Genetic

Cite this

Millar, K., Brown, J., Maule, J. C., Shibasaki, Y., Christie, S., Lawson, D., Anderson, S., Wilson-Annan, J. C., Devon, R., St Clair, D. M., Blackwood, D., Muir, W., & Porteous, D. J. (1998). A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes. Psychiatric Genetics, 8(3), 175-81.

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title = "A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes",

abstract = "A balanced t(1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related mental illness in a single large Scottish pedigree. We have constructed a long-range restriction map covering at least 3 Mb of the chromosome 11 breakpoint region and conducted searches for genes whose expression could be altered by the translocation, resulting in schizophrenia. Novel transcribed sequences of unknown function clustered around putative CpG islands, located approximately 500 kb and 700 kb above the breakpoint, represent the only evidence to date for expressed genes within the mapped region.",

keywords = "Cells, Cultured, Chromosomes, Artificial, Yeast, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 11, Cosmids, CpG Islands, Expressed Sequence Tags, Gene Library, Genetic Predisposition to Disease, Humans, In Situ Hybridization, Fluorescence, Pedigree, Polymerase Chain Reaction, Restriction Mapping, Schizophrenia, Scotland, Transcription, Genetic, Translocation, Genetic",

author = "Kirsty Millar and J Brown and Maule, {J C} and Y Shibasaki and S Christie and D Lawson and Susan Anderson and Wilson-Annan, {J C} and Rebecca Devon and {St Clair}, {D M} and Douglas Blackwood and Walter Muir and Porteous, {D J}",

year = "1998",

language = "English",

volume = "8",

pages = "175--81",

journal = "Psychiatric Genetics",

issn = "0955-8829",

publisher = "Lippincott Williams and Wilkins",

number = "3",

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Millar, K, Brown, J, Maule, JC, Shibasaki, Y, Christie, S, Lawson, D, Anderson, S, Wilson-Annan, JC, Devon, R, St Clair, DM, Blackwood, D, Muir, W & Porteous, DJ 1998, 'A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes', Psychiatric Genetics, vol. 8, no. 3, pp. 175-81.

TY - JOUR

T1 - A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes

AU - Millar, Kirsty

AU - Brown, J

AU - Maule, J C

AU - Shibasaki, Y

AU - Christie, S

AU - Lawson, D

AU - Anderson, Susan

AU - Wilson-Annan, J C

AU - Devon, Rebecca

AU - St Clair, D M

AU - Blackwood, Douglas

AU - Muir, Walter

AU - Porteous, D J

PY - 1998

Y1 - 1998

N2 - A balanced t(1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related mental illness in a single large Scottish pedigree. We have constructed a long-range restriction map covering at least 3 Mb of the chromosome 11 breakpoint region and conducted searches for genes whose expression could be altered by the translocation, resulting in schizophrenia. Novel transcribed sequences of unknown function clustered around putative CpG islands, located approximately 500 kb and 700 kb above the breakpoint, represent the only evidence to date for expressed genes within the mapped region.

AB - A balanced t(1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related mental illness in a single large Scottish pedigree. We have constructed a long-range restriction map covering at least 3 Mb of the chromosome 11 breakpoint region and conducted searches for genes whose expression could be altered by the translocation, resulting in schizophrenia. Novel transcribed sequences of unknown function clustered around putative CpG islands, located approximately 500 kb and 700 kb above the breakpoint, represent the only evidence to date for expressed genes within the mapped region.

KW - Cells, Cultured

KW - Chromosomes, Artificial, Yeast

KW - Chromosomes, Human, Pair 1

KW - Chromosomes, Human, Pair 11

KW - Cosmids

KW - CpG Islands

KW - Expressed Sequence Tags

KW - Gene Library

KW - Genetic Predisposition to Disease

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Pedigree

KW - Polymerase Chain Reaction

KW - Restriction Mapping

KW - Schizophrenia

KW - Scotland

KW - Transcription, Genetic

KW - Translocation, Genetic

M3 - Article

C2 - 9800219

SN - 0955-8829

VL - 8

SP - 175

EP - 181

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 3

ER -

A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes

Abstract

Keywords / Materials (for Non-textual outputs)

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Cite this