A matrix metalloproteinase activation probe for painting human tumours

Bethany Mills; Dominic Norberg; Kevin Dhaliwal; Ahsan R Akram; Mark Bradley; Alicia Megia-Fernandez

doi:10.1039/D0CC03886E

A matrix metalloproteinase activation probe for painting human tumours

Bethany Mills, Dominic Norberg, Kevin Dhaliwal, Ahsan R Akram, Mark Bradley, Alicia Megia-Fernandez

Research output: Contribution to journal › Article › peer-review

Abstract

A probe that allows specific ‘painting’ of human tumours is described. Probe activation was mediated by specific matrix metalloproteinases, resulting not only in disruption of a FRET pair, but in the generation of a fragment that “fluorescently paints” human tumours. This probe demonstrated rapid and effective human tumour labelling with the potential to allow margin detection during surgical resection.

Original language	English
Pages (from-to)	9962-9965
Journal	Chemical Communications
Volume	56
Issue number	7
DOIs	https://doi.org/10.1039/D0CC03886E
Publication status	Published - 16 Jul 2020

Access to Document

10.1039/D0CC03886E

d0cc03886eFinal published version, 3.69 MBLicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

http://xlink.rsc.org/?DOI=D0CC03886ELicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond
Bradley, M. (Principal Investigator), Bradley, M. (Principal Investigator), Dhaliwal, K. (Co-investigator), Dhaliwal, K. (Co-investigator), Haslett, C. (Co-investigator), Henderson, R. (Co-investigator), Walsh, T. (Co-investigator) & Walsh, T. (Co-investigator)
Engineering and Physical Sciences Research Council
1/01/19 → 1/06/23
Project: Research
Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging
Bradley, M. (Principal Investigator)
EPSRC
1/10/13 → 31/03/19
Project: Research

Ahsan Akram
- School of Regeneration and Repair - Personal Chair of Thoracic Oncology and Imaging
- Edinburgh Cancer Research Centre - Cancer Research UK Clinician Scientist
- Centre for Inflammation Research
Person: Academic: Research Active (Research Assistant)

Cite this

@article{93880dbe917e4ccf87a654d52c4d69ee,

title = "A matrix metalloproteinase activation probe for painting human tumours",

abstract = "A probe that allows specific {\textquoteleft}painting{\textquoteright} of human tumours is described. Probe activation was mediated by specific matrix metalloproteinases, resulting not only in disruption of a FRET pair, but in the generation of a fragment that “fluorescently paints” human tumours. This probe demonstrated rapid and effective human tumour labelling with the potential to allow margin detection during surgical resection.",

author = "Bethany Mills and Dominic Norberg and Kevin Dhaliwal and Akram, \{Ahsan R\} and Mark Bradley and Alicia Megia-Fernandez",

year = "2020",

month = jul,

day = "16",

doi = "10.1039/D0CC03886E",

language = "English",

volume = "56",

pages = " 9962--9965",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - A matrix metalloproteinase activation probe for painting human tumours

AU - Mills, Bethany

AU - Norberg, Dominic

AU - Dhaliwal, Kevin

AU - Akram, Ahsan R

AU - Bradley, Mark

AU - Megia-Fernandez, Alicia

PY - 2020/7/16

Y1 - 2020/7/16

N2 - A probe that allows specific ‘painting’ of human tumours is described. Probe activation was mediated by specific matrix metalloproteinases, resulting not only in disruption of a FRET pair, but in the generation of a fragment that “fluorescently paints” human tumours. This probe demonstrated rapid and effective human tumour labelling with the potential to allow margin detection during surgical resection.

AB - A probe that allows specific ‘painting’ of human tumours is described. Probe activation was mediated by specific matrix metalloproteinases, resulting not only in disruption of a FRET pair, but in the generation of a fragment that “fluorescently paints” human tumours. This probe demonstrated rapid and effective human tumour labelling with the potential to allow margin detection during surgical resection.

U2 - 10.1039/D0CC03886E

DO - 10.1039/D0CC03886E

M3 - Article

SN - 1359-7345

VL - 56

SP - 9962

EP - 9965

JO - Chemical Communications

JF - Chemical Communications

IS - 7

ER -

A matrix metalloproteinase activation probe for painting human tumours

Abstract

Access to Document

Fingerprint

Projects

EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond

Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging

Profiles

Ahsan Akram

Cite this