A meta-analysis for bovine tuberculosis resistance in dairy cattle

Smaragda Tsairidou, John A. Woolliams, A. R. Allen, R. A. Skuce, Stewart H McBride, Ricardo Pong-Wong, Oswald Matika, E.K. Finlay, D.P. Berry, D. G. Bradley, Stanley W J McDowell, Elizabeth J. Glass, Stephen C. Bishop

Research output: Contribution to conferencePaper

Abstract

Bovine tuberculosis (bTB) has been among the most persistent diseases in cattle. Genetic selection of disease resistant individuals may be a complementary approach to assist with disease control. The aim of this study was to conduct a meta-analysis on two dairy cattle populations with bTB phenotypes and SNP chip genotypes, identifying genomic regions underlying bTB resistance and testing genomic predictions by means of cross-validation. We identified a region on chromosome 6 likely to be associated with bTB resistance and confirmed that this chromosome as a whole contributes a major proportion of the observed variation in dataset. Genomic prediction for bTB was shown to be feasible even when different populations are combined, with the chromosome heritability results suggesting that the accuracy arises from the SNPs capturing linkage disequilibrium between markers and QTL as well as additive relationships between animals. Further studies on larger populations will be needed to confirm findings.
Original languageEnglish
Pages102
Publication statusPublished - 2014
EventProceedings, 10 th World Congress of Genetics Applied to Livestock Production - Canada, Vancouver, Canada
Duration: 17 Aug 201422 Aug 2014

Conference

ConferenceProceedings, 10 th World Congress of Genetics Applied to Livestock Production
CountryCanada
CityVancouver
Period17/08/1422/08/14

Keywords

  • Regional Heritability
  • Cross Validation
  • Genomic Selection
  • Disease Resistance
  • Bovine Tuberculosis

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