A meta-analysis for bovine tuberculosis resistance in dairy cattle

Smaragda Tsairidou; John A. Woolliams; A. R. Allen; R. A. Skuce; Stewart H McBride; Ricardo Pong-Wong; Oswald Matika; E.K. Finlay; D.P. Berry; D. G. Bradley; Stanley W J McDowell; Elizabeth J. Glass; Stephen C. Bishop

A meta-analysis for bovine tuberculosis resistance in dairy cattle

Smaragda Tsairidou, John A. Woolliams, A. R. Allen, R. A. Skuce, Stewart H McBride, Ricardo Pong-Wong, Oswald Matika, E.K. Finlay, D.P. Berry, D. G. Bradley, Stanley W J McDowell, Elizabeth J. Glass, Stephen C. Bishop

Royal (Dick) School of Veterinary Studies

Research output: Contribution to conference › Paper

Abstract / Description of output

Bovine tuberculosis (bTB) has been among the most persistent diseases in cattle. Genetic selection of disease resistant individuals may be a complementary approach to assist with disease control. The aim of this study was to conduct a meta-analysis on two dairy cattle populations with bTB phenotypes and SNP chip genotypes, identifying genomic regions underlying bTB resistance and testing genomic predictions by means of cross-validation. We identified a region on chromosome 6 likely to be associated with bTB resistance and confirmed that this chromosome as a whole contributes a major proportion of the observed variation in dataset. Genomic prediction for bTB was shown to be feasible even when different populations are combined, with the chromosome heritability results suggesting that the accuracy arises from the SNPs capturing linkage disequilibrium between markers and QTL as well as additive relationships between animals. Further studies on larger populations will be needed to confirm findings.

Original language	English
Pages	102
Publication status	Published - 2014
Event	Proceedings, 10 th World Congress of Genetics Applied to Livestock Production - Canada, Vancouver, Canada Duration: 17 Aug 2014 → 22 Aug 2014

Conference

Conference	Proceedings, 10 th World Congress of Genetics Applied to Livestock Production
Country/Territory	Canada
City	Vancouver
Period	17/08/14 → 22/08/14

Keywords / Materials (for Non-textual outputs)

Regional Heritability
Cross Validation
Genomic Selection
Disease Resistance
Bovine Tuberculosis

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Tsairidou, S., Woolliams, J. A., Allen, A. R., Skuce, R. A., McBride, S. H., Pong-Wong, R., Matika, O., Finlay, E. K., Berry, D. P., Bradley, D. G., McDowell, S. W. J., Glass, E. J., & Bishop, S. C. (2014). A meta-analysis for bovine tuberculosis resistance in dairy cattle. 102. Paper presented at Proceedings, 10 th World Congress of Genetics Applied to Livestock Production, Vancouver, Canada.

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title = "A meta-analysis for bovine tuberculosis resistance in dairy cattle",

abstract = "Bovine tuberculosis (bTB) has been among the most persistent diseases in cattle. Genetic selection of disease resistant individuals may be a complementary approach to assist with disease control. The aim of this study was to conduct a meta-analysis on two dairy cattle populations with bTB phenotypes and SNP chip genotypes, identifying genomic regions underlying bTB resistance and testing genomic predictions by means of cross-validation. We identified a region on chromosome 6 likely to be associated with bTB resistance and confirmed that this chromosome as a whole contributes a major proportion of the observed variation in dataset. Genomic prediction for bTB was shown to be feasible even when different populations are combined, with the chromosome heritability results suggesting that the accuracy arises from the SNPs capturing linkage disequilibrium between markers and QTL as well as additive relationships between animals. Further studies on larger populations will be needed to confirm findings.",

keywords = "Regional Heritability, Cross Validation, Genomic Selection, Disease Resistance, Bovine Tuberculosis",

author = "Smaragda Tsairidou and Woolliams, {John A.} and Allen, {A. R.} and Skuce, {R. A.} and McBride, {Stewart H} and Ricardo Pong-Wong and Oswald Matika and E.K. Finlay and D.P. Berry and Bradley, {D. G.} and McDowell, {Stanley W J} and Glass, {Elizabeth J.} and Bishop, {Stephen C.}",

year = "2014",

language = "English",

pages = "102",

note = "Proceedings, 10 th World Congress of Genetics Applied to Livestock Production ; Conference date: 17-08-2014 Through 22-08-2014",

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Tsairidou, S, Woolliams, JA, Allen, AR, Skuce, RA, McBride, SH, Pong-Wong, R , Matika, O, Finlay, EK, Berry, DP, Bradley, DG, McDowell, SWJ, Glass, EJ & Bishop, SC 2014, 'A meta-analysis for bovine tuberculosis resistance in dairy cattle', Paper presented at Proceedings, 10 th World Congress of Genetics Applied to Livestock Production, Vancouver, Canada, 17/08/14 - 22/08/14 pp. 102.

TY - CONF

T1 - A meta-analysis for bovine tuberculosis resistance in dairy cattle

AU - Tsairidou, Smaragda

AU - Woolliams, John A.

AU - Allen, A. R.

AU - Skuce, R. A.

AU - McBride, Stewart H

AU - Pong-Wong, Ricardo

AU - Matika, Oswald

AU - Finlay, E.K.

AU - Berry, D.P.

AU - Bradley, D. G.

AU - McDowell, Stanley W J

AU - Glass, Elizabeth J.

AU - Bishop, Stephen C.

PY - 2014

Y1 - 2014

N2 - Bovine tuberculosis (bTB) has been among the most persistent diseases in cattle. Genetic selection of disease resistant individuals may be a complementary approach to assist with disease control. The aim of this study was to conduct a meta-analysis on two dairy cattle populations with bTB phenotypes and SNP chip genotypes, identifying genomic regions underlying bTB resistance and testing genomic predictions by means of cross-validation. We identified a region on chromosome 6 likely to be associated with bTB resistance and confirmed that this chromosome as a whole contributes a major proportion of the observed variation in dataset. Genomic prediction for bTB was shown to be feasible even when different populations are combined, with the chromosome heritability results suggesting that the accuracy arises from the SNPs capturing linkage disequilibrium between markers and QTL as well as additive relationships between animals. Further studies on larger populations will be needed to confirm findings.

AB - Bovine tuberculosis (bTB) has been among the most persistent diseases in cattle. Genetic selection of disease resistant individuals may be a complementary approach to assist with disease control. The aim of this study was to conduct a meta-analysis on two dairy cattle populations with bTB phenotypes and SNP chip genotypes, identifying genomic regions underlying bTB resistance and testing genomic predictions by means of cross-validation. We identified a region on chromosome 6 likely to be associated with bTB resistance and confirmed that this chromosome as a whole contributes a major proportion of the observed variation in dataset. Genomic prediction for bTB was shown to be feasible even when different populations are combined, with the chromosome heritability results suggesting that the accuracy arises from the SNPs capturing linkage disequilibrium between markers and QTL as well as additive relationships between animals. Further studies on larger populations will be needed to confirm findings.

KW - Regional Heritability

KW - Cross Validation

KW - Genomic Selection

KW - Disease Resistance

KW - Bovine Tuberculosis

M3 - Paper

SP - 102

T2 - Proceedings, 10 th World Congress of Genetics Applied to Livestock Production

Y2 - 17 August 2014 through 22 August 2014

ER -

A meta-analysis for bovine tuberculosis resistance in dairy cattle

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Conference

Keywords / Materials (for Non-textual outputs)

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Cite this