A Molecular Doorstop Ensures a Trickle through Translational Repression

Matthew Brook; Richard W. P. Smith; Nicola K. Gray

doi:10.1016/j.cell.2012.03.010

A Molecular Doorstop Ensures a Trickle through Translational Repression

Matthew Brook, Richard W. P. Smith, Nicola K. Gray

Deanery of Clinical Sciences

Research output: Contribution to journal › Editorial › peer-review

Abstract / Description of output

Switching mRNA translation off and on is central to regulated gene expression, but what mechanisms moderate the extent of switch-off? Yao et al. describe how basal expression from interferon-gamma-induced transcripts is maintained during mRNA-specific translational repression. This antagonistic mechanism utilizes a truncated RNA-binding factor generated by a unique alternative polyadenylation event.

Original language	English
Pages (from-to)	13-15
Number of pages	3
Journal	Cell
Volume	149
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2012.03.010
Publication status	Published - 30 Mar 2012

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10.1016/j.cell.2012.03.010

http://www.cell.com/retrieve/pii/S009286741200339X

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title = "A Molecular Doorstop Ensures a Trickle through Translational Repression",

abstract = "Switching mRNA translation off and on is central to regulated gene expression, but what mechanisms moderate the extent of switch-off? Yao et al. describe how basal expression from interferon-gamma-induced transcripts is maintained during mRNA-specific translational repression. This antagonistic mechanism utilizes a truncated RNA-binding factor generated by a unique alternative polyadenylation event.",

author = "Matthew Brook and Smith, {Richard W. P.} and Gray, {Nicola K.}",

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AU - Brook, Matthew

AU - Smith, Richard W. P.

AU - Gray, Nicola K.

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N2 - Switching mRNA translation off and on is central to regulated gene expression, but what mechanisms moderate the extent of switch-off? Yao et al. describe how basal expression from interferon-gamma-induced transcripts is maintained during mRNA-specific translational repression. This antagonistic mechanism utilizes a truncated RNA-binding factor generated by a unique alternative polyadenylation event.

AB - Switching mRNA translation off and on is central to regulated gene expression, but what mechanisms moderate the extent of switch-off? Yao et al. describe how basal expression from interferon-gamma-induced transcripts is maintained during mRNA-specific translational repression. This antagonistic mechanism utilizes a truncated RNA-binding factor generated by a unique alternative polyadenylation event.

U2 - 10.1016/j.cell.2012.03.010

DO - 10.1016/j.cell.2012.03.010

M3 - Editorial

SN - 0092-8674

VL - 149

SP - 13

EP - 15

JO - Cell

JF - Cell

IS - 1

ER -

A Molecular Doorstop Ensures a Trickle through Translational Repression

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