A monoclonal antibody which reacts specifically with a population of bovine lymphocytes lacking B cell and T cell markers

Ivan Morrison, N D MacHugh, Albert Bensaid, Bruno Goddeeris, A.J. Teale, DJ McKeever

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract / Description of output

In the last few years a number of monoclonal antibodies (MAb) specific for bovine T lymphocytes has been produced. These include antibodies which react with the sheep erythrocyte receptor (designated BoT2) (Davis et al., in press) and thus can be used as pan-T cell markers, and antibodies to the two major subset markers BoT4 and B0T8 (Baldwin et al., 1986; Ellis et al., 1986). When these antibodies are used, in conjunction with reagents that identify B lymphocytes and monocytes, to phenotype bovine leukocytes, there is a residual population of lymphocytes comprising 10–20% of peripheral blood mononuclear cells (PBM) that is unreactive with these reagents. Recently, we have produced a MAb that reacts with a proportion of these “null” lymphocytes. Herein, we will summarise our findings with this antibody.
Original languageEnglish
Title of host publicationHistophysiology of the Immune System
Subtitle of host publicationThe Life History, Organization, and Interactions of Its Cell Populations
EditorsSigbjørn Fossum, Bent Rolstad
PublisherSpringer US
Pages591-6
Number of pages6
Volume237
EditionAdvances in Experimental Medicine and Biology
ISBN (Electronic)978-1-4684-5535-9
ISBN (Print)978-1-4684-5537-3
DOIs
Publication statusPublished - 1988

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Antibodies, Monoclonal/immunology
  • Cattle
  • Flow Cytometry
  • Immunoenzyme Techniques
  • Lymphocyte Activation
  • Lymphocytes/classification
  • Lymphocytes/immunology
  • Lymphoid Tissue/cytology
  • Precipitin Tests

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