Abstract / Description of output
GNAS/Gnas encodes G(s)alpha that is mainly biallelically expressed but shows imprinted expression in some tissues. In Albright Hereditary Osteodystrophy (AHO) heterozygous loss of function mutations of GNAS can result in ectopic ossification that tends to be superficial and attributable to haploinsufficiency of biallelically expressed G(s)alpha. Oed-Sml is a point missense mutation in exon 6 of the orthologous mouse locus Gnas. We report here both the late onset ossification and occurrence of benign cutaneous fibroepithelial polyps in Oed-Sml. These phenotypes are seen on both maternal and paternal inheritance of the mutant allele and are therefore due to an effect on biallelically expressed G(s)alpha. The ossification is confined to subcutaneous tissues and so resembles the ossification observed with AHO. Our mouse model is the first with both subcutaneous ossification and fibroepithelial polyps related to G(s)alpha deficiency. It is also the first mouse model described with a clinically relevant phenotype associated with a point mutation in G(s)alpha and may be useful in investigations of the mechanisms of heterotopic bone formation. Together with earlier results, our findings indicate that G(s)alpha signalling pathways play a vital role in repressing ectopic bone formation.
Original language | English |
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Article number | ARTN e51835 |
Number of pages | 9 |
Journal | PLoS ONE |
Volume | 7 |
Issue number | 12 |
DOIs | |
Publication status | Published - 19 Dec 2012 |
Keywords / Materials (for Non-textual outputs)
- HORMONE RESISTANCE
- ALBRIGHT-HEREDITARY-OSTEODYSTROPHY
- PROTEIN ALPHA-SUBUNIT
- STIMULATORY G-PROTEIN
- HETEROTOPIC OSSIFICATION
- PSEUDOHYPOPARATHYROIDISM TYPE 1A
- INACTIVATING MUTATIONS
- IMPRINTING CONTROL REGION
- G(S)ALPHA GENE GNAS1
- EXTRASKELETAL OSSIFICATION