A multi-institutional international study of risk factors for hematoma after thyroidectomy

Michael J. Campbell, Kelly L. McCoy, Wen T. Shen, Sally E. Carty, Carrie C. Lubitz, Jacob Moalem, Matthew Nehs, Tammy Holm, David Y. Greenblatt, Danielle Press, Xiaoxi Feng, Allan E. Siperstein, Elliot Mitmaker, Cassandre Benay, Roger Tabah, Sarah C. Oltmann, Herbert Chen, Rebecca S. Sippel, Andrew Brekke, Menno R. VriensLutske Lodewijk, Antonia E. Stephen, Sapna Nagar, Peter Angelos, Maher Ghanem, Jason D. Prescott, Martha A. Zeiger, Patricia Aragon Han, Cord Sturgeon, Dina M. Elaraj, Iain J. Nixon, Snehal G. Patel, Stephen W. Bayles, Rachel Heneghan, Peter Ochieng, Marlon A. Guerrero, Daniel T. Ruan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background Cervical hematoma can be a potentially fatal complication after thyroidectomy, but its risk factors and timing remain poorly understood. Methods We conducted a retrospective, case-control study identifying 207 patients from 15 institutions in 3 countries who developed a hematoma requiring return to the operating room (OR) after thyroidectomy. Results Forty-seven percent of hematoma patients returned to the OR within 6 hours and 79% within 24 hours of their thyroidectomy. On univariate analysis, hematoma patients were older, more likely to be male, smokers, on active antiplatelet/anticoagulation medications, have Graves' disease, a bilateral thyroidectomy, a drain placed, a concurrent parathyroidectomy, and benign pathology. Hematoma patients also had more blood loss, larger thyroids, lower temperatures, and higher blood pressures postoperatively. On multivariate analysis, independent associations with hematoma were use of a drain (odds ratio, 2.79), Graves' disease (odds ratio, 2.43), benign pathology (odds ratio, 2.22), antiplatelet/anticoagulation medications (odds ratio, 2.12), use of a hemostatic agent (odds ratio, 1.97), and increased thyroid mass (odds ratio, 1.01). Conclusion A significant number of patients with a postoperative hematoma present >6 hours after thyroidectomy. Hematoma is associated with patients who have a drain or hemostatic agent, have Graves' disease, are actively using antiplatelet/ anticoagulation medications or have large thyroids. Surgeons should consider these factors when individualizing patient disposition after thyroidectomy.

Original languageEnglish
Pages (from-to)1283-1291
Number of pages9
JournalSurgery (United States)
Issue number6
Publication statusPublished - 1 Dec 2013


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