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Abstract / Description of output
We report a platform combining multicomponent reaction synthesis and automated cell-based screening to develop biocompatible NIR-BODIPY fluorophores. From a library of over 60 fluorophores, we optimised compound NIRBD-62c as a multimodal probe with suitable properties for STED super-resolution and fluorescence lifetime imaging. Furthermore, we employed NIRBD-62c for imaging trafficking inside cells and to examine how pharmacological inhibitors can alter the vesicular traffic between intracellular compartments and the plasma membrane.
Original language | English |
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Journal | RSC Chemical Biology |
Early online date | 25 Aug 2022 |
DOIs | |
Publication status | E-pub ahead of print - 25 Aug 2022 |
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Dive into the research topics of 'A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging'. Together they form a unique fingerprint.Projects
- 2 Finished
Equipment
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Edinburgh Drug Discovery
Asier Unciti-Broceta (Manager), Scott Webster (Manager) & Neil Carragher (Manager)
Deanery of Molecular, Genetic and Population Health SciencesFacility/equipment: Facility