A negative loop within the nuclear pore complex controls global chromatin organization

Manuel Breuer, Hiroyuki Ohkura*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The nuclear pore complex (NPC) tethers chromatin to create an environment for gene regulation, but little is known how this activity is regulated to avoid excessive tethering of the genome. Here we propose a negative regulatory loop within the NPC controlling the chromatin attachment state, in which Nup155 and Nup93 recruit Nup62 to suppress chromatin tethering by Nup155. Depletion of Nup62 severely disrupts chromatin distribution in nuclei of female germlines and somatic cells, which can be reversed by co-depleting Nup155. Thus this universal regulatory system within the NPC is crucial to control large-scale chromatin
organisation in the nucleus.
Original languageEnglish
Pages (from-to)1789-1794
Number of pages6
JournalGenes & Development
Volume29
Issue number17
DOIs
Publication statusPublished - 1 Sep 2015

Keywords

  • chromatin
  • drosophila
  • karyosome
  • meiosis
  • nuclear pore

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