Projects per year
Abstract / Description of output
The nuclear pore complex (NPC) tethers chromatin to create an environment for gene regulation, but little is known how this activity is regulated to avoid excessive tethering of the genome. Here we propose a negative regulatory loop within the NPC controlling the chromatin attachment state, in which Nup155 and Nup93 recruit Nup62 to suppress chromatin tethering by Nup155. Depletion of Nup62 severely disrupts chromatin distribution in nuclei of female germlines and somatic cells, which can be reversed by co-depleting Nup155. Thus this universal regulatory system within the NPC is crucial to control large-scale chromatin
organisation in the nucleus.
organisation in the nucleus.
Original language | English |
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Pages (from-to) | 1789-1794 |
Number of pages | 6 |
Journal | Genes & Development |
Volume | 29 |
Issue number | 17 |
DOIs | |
Publication status | Published - 1 Sept 2015 |
Keywords / Materials (for Non-textual outputs)
- chromatin
- drosophila
- karyosome
- meiosis
- nuclear pore
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Dive into the research topics of 'A negative loop within the nuclear pore complex controls global chromatin organization'. Together they form a unique fingerprint.Projects
- 1 Finished
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The specialised apparatus for meiotic chromosome segregation in oocytes
1/12/12 → 30/11/18
Project: Research
Profiles
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Hiroyuki Ohkura
- School of Biological Sciences - Personal Chair in Cell Biology
Person: Academic: Research Active