A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

J. Hall, H. C. Whalley, D. E. Job, B. J. Baig, A. M. McIntosh, K. L. Evans, P. A. Thomson, D. J. Porteous, D. G. Cunningham-Owens, E. C. Johnstone, S. M. Lawrie

Research output: Contribution to journalArticlepeer-review

Abstract

NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ.
Original languageEnglish
Pages (from-to)1477-1478
Number of pages2
JournalNature Neuroscience
Volume9
Issue number12
DOIs
Publication statusPublished - 2006

Keywords

  • Adult *Brain Mapping Cerebral Cortex/*physiopathology Cognition/physiology Cohort Studies Female Frontal Lobe/physiopathology *Genetic Predisposition to Disease Humans Intelligence/genetics Male Microsatellite Repeats/genetics Nerve Tissue Proteins/*genetics/metabolism Polymorphism, Single Nucleotide Psychotic Disorders/complications/*genetics Risk Factors Schizophrenia/complications/*genetics Temporal Lobe/physiopathology

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