A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

J. Hall; H. C. Whalley; D. E. Job; B. J. Baig; A. M. McIntosh; K. L. Evans; P. A. Thomson; D. J. Porteous; D. G. Cunningham-Owens; E. C. Johnstone; S. M. Lawrie

doi:10.1038/nn1795

A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

J. Hall, H. C. Whalley, D. E. Job, B. J. Baig, A. M. McIntosh, K. L. Evans, P. A. Thomson, D. J. Porteous, D. G. Cunningham-Owens, E. C. Johnstone, S. M. Lawrie

Research output: Contribution to journal › Article › peer-review

Abstract

NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ.

Original language	English
Pages (from-to)	1477-1478
Number of pages	2
Journal	Nature Neuroscience
Volume	9
Issue number	12
DOIs	https://doi.org/10.1038/nn1795
Publication status	Published - 2006

Keywords

Adult *Brain Mapping Cerebral Cortex/*physiopathology Cognition/physiology Cohort Studies Female Frontal Lobe/physiopathology *Genetic Predisposition to Disease Humans Intelligence/genetics Male Microsatellite Repeats/genetics Nerve Tissue Proteins/*genetics/metabolism Polymorphism, Single Nucleotide Psychotic Disorders/complications/*genetics Risk Factors Schizophrenia/complications/*genetics Temporal Lobe/physiopathology

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10.1038/nn1795

http://www.nature.com/neuro/journal/v9/n12/full/nn1795.html

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title = "A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms",

abstract = "NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ.",

keywords = "Adult *Brain Mapping Cerebral Cortex/*physiopathology Cognition/physiology Cohort Studies Female Frontal Lobe/physiopathology *Genetic Predisposition to Disease Humans Intelligence/genetics Male Microsatellite Repeats/genetics Nerve Tissue Proteins/*genetics/metabolism Polymorphism, Single Nucleotide Psychotic Disorders/complications/*genetics Risk Factors Schizophrenia/complications/*genetics Temporal Lobe/physiopathology",

author = "J. Hall and Whalley, {H. C.} and Job, {D. E.} and Baig, {B. J.} and McIntosh, {A. M.} and Evans, {K. L.} and Thomson, {P. A.} and Porteous, {D. J.} and Cunningham-Owens, {D. G.} and Johnstone, {E. C.} and Lawrie, {S. M.}",

note = "Dec A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms Journal Article Research Support, Non-U.S. Gov't United States eng",

year = "2006",

doi = "10.1038/nn1795",

language = "English",

volume = "9",

pages = "1477--1478",

journal = "Nature Neuroscience",

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publisher = "Nature Publishing Group",

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A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. / Hall, J.; Whalley, H. C.; Job, D. E.; Baig, B. J.; McIntosh, A. M.; Evans, K. L.; Thomson, P. A.; Porteous, D. J.; Cunningham-Owens, D. G.; Johnstone, E. C.; Lawrie, S. M.

In: Nature Neuroscience, Vol. 9, No. 12, 2006, p. 1477-1478.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

AU - Hall, J.

AU - Whalley, H. C.

AU - Job, D. E.

AU - Baig, B. J.

AU - McIntosh, A. M.

AU - Evans, K. L.

AU - Thomson, P. A.

AU - Porteous, D. J.

AU - Cunningham-Owens, D. G.

AU - Johnstone, E. C.

AU - Lawrie, S. M.

N1 - Dec A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms Journal Article Research Support, Non-U.S. Gov't United States eng

PY - 2006

Y1 - 2006

N2 - NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ.

AB - NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ.

KW - Adult Brain Mapping Cerebral Cortex/physiopathology Cognition/physiology Cohort Studies Female Frontal Lobe/physiopathology Genetic Predisposition to Disease Humans Intelligence/genetics Male Microsatellite Repeats/genetics Nerve Tissue Proteins/genetics/

U2 - 10.1038/nn1795

DO - 10.1038/nn1795

M3 - Article

C2 - 17072305

VL - 9

SP - 1477

EP - 1478

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 12

ER -

A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

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Keywords

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