A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang, Agnieszka Kulczynska, David J. Webb, Ian L. Megson, Nigel P. Botting

Research output: Contribution to journalArticlepeer-review

Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

Original languageEnglish
Pages (from-to)1389-1391
Number of pages3
JournalChemical Communications
Volume49
Issue number14
Early online date21 Dec 2012
DOIs
Publication statusPublished - 18 Feb 2013

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