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This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
FingerprintDive into the research topics of 'A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation'. Together they form a unique fingerprint.
- 1 Finished
Synthesis and biological assessment of novel analogues of N-hydroxyarginine: potential as reno-selective vasodilatation for acute renal failure.
Webb, D. & Megson, I.
1/10/03 → 30/09/07