A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang; Agnieszka Kulczynska; David J. Webb; Ian L. Megson; Nigel P. Botting

doi:10.1039/C2CC38382A

A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang, Agnieszka Kulczynska, David J. Webb, Ian L. Megson, Nigel P. Botting

Research output: Contribution to journal › Article › peer-review

Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

Original language	English
Pages (from-to)	1389-1391
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	14
Early online date	21 Dec 2012
DOIs	https://doi.org/10.1039/C2CC38382A https://doi.org/10.1039/c2cc38382a
Publication status	Published - 18 Feb 2013

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A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation
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http://pubs.rsc.org/en/Content/ArticleLanding/2013/CC/c2cc38382a

Synthesis and biological assessment of novel analogues of N-hydroxyarginine: potential as reno-selective vasodilatation for acute renal failure.
Webb, D. (Principal Investigator) & Megson, I. (Co-investigator)
UK-based charities
1/10/03 → 30/09/07
Project: Research

Cite this

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title = "A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation",

abstract = "This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).",

author = "Qingzhi Zhang and Agnieszka Kulczynska and Webb, \{David J.\} and Megson, \{Ian L.\} and Botting, \{Nigel P.\}",

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AU - Webb, David J.

AU - Megson, Ian L.

AU - Botting, Nigel P.

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AB - This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

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A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation

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Synthesis and biological assessment of novel analogues of N-hydroxyarginine: potential as reno-selective vasodilatation for acute renal failure.

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