A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa

M A Sathar; P N Soni; R Pegoraro; P Simmonds; D B Smith; A P Dhillon; G M Dusheiko

doi:10.1016/S0168-1702(99)00090-8

A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa

M A Sathar, P N Soni, R Pegoraro, P Simmonds, D B Smith, A P Dhillon, G M Dusheiko

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Phylogenetic analysis of the 5' non-coding region (5'NCR) sequences has demonstrated that GB virus C/hepatitis G virus (GBV-C/HGV) can be separated into three major groups that correlate with the geographic origin of the isolate. Sequence analysis of the 5'NCR of 54 GBV-C/HGV isolates from 31 blood donors, 11 haemodialysis patients and 12 patients with chronic liver disease suggests the presence of a new variant of GBV-C/HGV in the province of KwaZulu Natal, South Africa. Eleven isolates grouped as group 1 variants (bootstrap support, 90%) found predominantly in West and Central Africa, a further six isolates grouped as group 2 variants (bootstrap support, 58%) found in Europe and North America; five of which grouped as 2a (bootstrap support, 91%) and one as 2b (bootstrap support, 87%), the latter also includes isolates from Japan, East Africa and Pakistan. Although the remaining 37 GBV-C/HGV isolates were more closely related to group 1 variants (bootstrap support, 90%), they formed a cluster, which was distinct from all other known GBV-C/HGV sequences. None of the South African isolates grouped with group 3 variants described from Southeast Asia. Three variants of GBV-C/HGV exist in KwaZulu Natal: groups 1, 2 and a new variant, which is distinct from other African isolates.

Original language	English
Pages (from-to)	151-60
Number of pages	10
Journal	Virus Research
Volume	64
Issue number	2
DOIs	https://doi.org/10.1016/S0168-1702(99)00090-8
Publication status	Published - Nov 1999

Keywords / Materials (for Non-textual outputs)

Base Sequence
Blood Donors
Chronic Disease
Flaviviridae
Hepatitis, Viral, Human
Humans
Liver Diseases
Molecular Sequence Data
Phylogeny
RNA, Viral
Renal Dialysis
Sequence Homology, Nucleic Acid
South Africa

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10.1016/S0168-1702(99)00090-8

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title = "A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa",

abstract = "Phylogenetic analysis of the 5' non-coding region (5'NCR) sequences has demonstrated that GB virus C/hepatitis G virus (GBV-C/HGV) can be separated into three major groups that correlate with the geographic origin of the isolate. Sequence analysis of the 5'NCR of 54 GBV-C/HGV isolates from 31 blood donors, 11 haemodialysis patients and 12 patients with chronic liver disease suggests the presence of a new variant of GBV-C/HGV in the province of KwaZulu Natal, South Africa. Eleven isolates grouped as group 1 variants (bootstrap support, 90%) found predominantly in West and Central Africa, a further six isolates grouped as group 2 variants (bootstrap support, 58%) found in Europe and North America; five of which grouped as 2a (bootstrap support, 91%) and one as 2b (bootstrap support, 87%), the latter also includes isolates from Japan, East Africa and Pakistan. Although the remaining 37 GBV-C/HGV isolates were more closely related to group 1 variants (bootstrap support, 90%), they formed a cluster, which was distinct from all other known GBV-C/HGV sequences. None of the South African isolates grouped with group 3 variants described from Southeast Asia. Three variants of GBV-C/HGV exist in KwaZulu Natal: groups 1, 2 and a new variant, which is distinct from other African isolates.",

keywords = "Base Sequence, Blood Donors, Chronic Disease, Flaviviridae, Hepatitis, Viral, Human, Humans, Liver Diseases, Molecular Sequence Data, Phylogeny, RNA, Viral, Renal Dialysis, Sequence Homology, Nucleic Acid, South Africa",

author = "Sathar, {M A} and Soni, {P N} and R Pegoraro and P Simmonds and Smith, {D B} and Dhillon, {A P} and Dusheiko, {G M}",

year = "1999",

month = nov,

doi = "10.1016/S0168-1702(99)00090-8",

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T1 - A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa

AU - Sathar, M A

AU - Soni, P N

AU - Pegoraro, R

AU - Simmonds, P

AU - Smith, D B

AU - Dhillon, A P

AU - Dusheiko, G M

PY - 1999/11

Y1 - 1999/11

N2 - Phylogenetic analysis of the 5' non-coding region (5'NCR) sequences has demonstrated that GB virus C/hepatitis G virus (GBV-C/HGV) can be separated into three major groups that correlate with the geographic origin of the isolate. Sequence analysis of the 5'NCR of 54 GBV-C/HGV isolates from 31 blood donors, 11 haemodialysis patients and 12 patients with chronic liver disease suggests the presence of a new variant of GBV-C/HGV in the province of KwaZulu Natal, South Africa. Eleven isolates grouped as group 1 variants (bootstrap support, 90%) found predominantly in West and Central Africa, a further six isolates grouped as group 2 variants (bootstrap support, 58%) found in Europe and North America; five of which grouped as 2a (bootstrap support, 91%) and one as 2b (bootstrap support, 87%), the latter also includes isolates from Japan, East Africa and Pakistan. Although the remaining 37 GBV-C/HGV isolates were more closely related to group 1 variants (bootstrap support, 90%), they formed a cluster, which was distinct from all other known GBV-C/HGV sequences. None of the South African isolates grouped with group 3 variants described from Southeast Asia. Three variants of GBV-C/HGV exist in KwaZulu Natal: groups 1, 2 and a new variant, which is distinct from other African isolates.

AB - Phylogenetic analysis of the 5' non-coding region (5'NCR) sequences has demonstrated that GB virus C/hepatitis G virus (GBV-C/HGV) can be separated into three major groups that correlate with the geographic origin of the isolate. Sequence analysis of the 5'NCR of 54 GBV-C/HGV isolates from 31 blood donors, 11 haemodialysis patients and 12 patients with chronic liver disease suggests the presence of a new variant of GBV-C/HGV in the province of KwaZulu Natal, South Africa. Eleven isolates grouped as group 1 variants (bootstrap support, 90%) found predominantly in West and Central Africa, a further six isolates grouped as group 2 variants (bootstrap support, 58%) found in Europe and North America; five of which grouped as 2a (bootstrap support, 91%) and one as 2b (bootstrap support, 87%), the latter also includes isolates from Japan, East Africa and Pakistan. Although the remaining 37 GBV-C/HGV isolates were more closely related to group 1 variants (bootstrap support, 90%), they formed a cluster, which was distinct from all other known GBV-C/HGV sequences. None of the South African isolates grouped with group 3 variants described from Southeast Asia. Three variants of GBV-C/HGV exist in KwaZulu Natal: groups 1, 2 and a new variant, which is distinct from other African isolates.

KW - Base Sequence

KW - Blood Donors

KW - Chronic Disease

KW - Flaviviridae

KW - Hepatitis, Viral, Human

KW - Humans

KW - Liver Diseases

KW - Molecular Sequence Data

KW - Phylogeny

KW - RNA, Viral

KW - Renal Dialysis

KW - Sequence Homology, Nucleic Acid

KW - South Africa

U2 - 10.1016/S0168-1702(99)00090-8

DO - 10.1016/S0168-1702(99)00090-8

M3 - Article

C2 - 10518711

SN - 0168-1702

VL - 64

SP - 151

EP - 160

JO - Virus Research

JF - Virus Research

IS - 2

ER -

A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa

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Keywords / Materials (for Non-textual outputs)

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