A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'

Frank J Gunn-Moore; Gavin I Welsh; Lissa R Herron; Frances Brannigan; Kanamarlapudi Venkateswarlu; Stewart Gillespie; Margaret Brandwein-Gensler; Rashna Madan; Jeremy M Tavaré; Peter J Brophy; Michael B Prystowsky; Simon Guild

doi:10.1016/j.febslet.2005.07.097

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'

Frank J Gunn-Moore, Gavin I Welsh, Lissa R Herron, Frances Brannigan, Kanamarlapudi Venkateswarlu, Stewart Gillespie, Margaret Brandwein-Gensler, Rashna Madan, Jeremy M Tavaré, Peter J Brophy, Michael B Prystowsky, Simon Guild

Research output: Contribution to journal › Article › peer-review

Abstract

The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.

Original language	English
Pages (from-to)	5089-94
Number of pages	6
Journal	FEBS Letters
Volume	579
Issue number	22
DOIs	https://doi.org/10.1016/j.febslet.2005.07.097
Publication status	Published - 2005

Keywords

Adaptor Proteins, Signal Transducing/genetics
Adaptor Proteins, Signal Transducing/metabolism
Amino Acid Sequence
Animals
Blood Proteins/genetics
Blood Proteins/metabolism
Cell Line
Cell Membrane/chemistry
Cell Membrane/metabolism
Cytoskeletal Proteins/genetics
Cytoskeletal Proteins/metabolism
Humans
Membrane Proteins/genetics
Membrane Proteins/metabolism
Microfilament Proteins/genetics
Microfilament Proteins/metabolism
Molecular Sequence Data
Multigene Family
Phospholipids/metabolism
Phosphoproteins/genetics
Phosphoproteins/metabolism
Protein Binding
Protein Structure, Tertiary
Rats
Recombinant Fusion Proteins/genetics
Recombinant Fusion Proteins/metabolism
Sequence Alignment

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10.1016/j.febslet.2005.07.097

A novel 4.1 ezrin radixin moesin (FERM)-containing protein,Willin
Copyright 2005 Federation of European Biochemical Societies
Final published version, 450 KB

Functional genomics of axon-glial interactions in the CNS.
Brophy, P.
MRC
1/07/01 → 31/12/06
Project: Research

Cite this

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title = "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'",

abstract = "The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.",

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AU - Venkateswarlu, Kanamarlapudi

AU - Gillespie, Stewart

AU - Brandwein-Gensler, Margaret

AU - Madan, Rashna

AU - Tavaré, Jeremy M

AU - Brophy, Peter J

AU - Prystowsky, Michael B

AU - Guild, Simon

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KW - Rats

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A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'

Abstract

Keywords

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Projects

Functional genomics of axon-glial interactions in the CNS.

Cite this