Projects per year
A rapid and efficient method for the detection of hydroxyapatite (HAP) has been developed which shows superiority to existing well-established methods. This fluorescein-bisphosphonate probe is highly selective for HAP over other calcium minerals and is capable of detecting lower levels of calcification in cellular models than either hydrochloric acid-based calcium leaching assays or the Alizarin S stain. The probe has been shown to be effective in both in vitro vascular calcification models and in vitro bone calcification models. Moreover we have demonstrated binding of this probe to vascular calcification in rat aorta and to areas of microcalcification, in human vascular tissue, beyond the resolution of computed tomography in human atherosclerotic plaques. Fluorescein-BP is therefore a highly sensitive and specific imaging probe for the detection of vascular calcification, with the potential to improve not only ex vivo assessments of HAP deposition but also the detection of vascular microcalcification in humans.
|Early online date||26 Nov 2018|
|Publication status||Published - 26 Nov 2018|
FingerprintDive into the research topics of 'A novel fluorescein-bisphosphonate based diagnostic tool for the detection of hydroxyapatite in both cell and tissue models'. Together they form a unique fingerprint.
- 4 Finished
Molecular THoracic imAging and bioiNformatics Approaches TO Sudden death (THANATOS) Study
Newby, D., Bouhaidar, R. & Moss, A.
UK central government bodies/local authorities, health and hospital authorities
1/06/18 → 31/01/19
An Intermediate Clinical Research Fellowship in Cardiovascular Non- Invasive Molecular Imaging
1/12/14 → 30/11/21
A HUB FOR ENGINEERING AND EXPLOITING THE STEM CELL NICHE
1/11/13 → 31/03/18
A novel fluorescein-bisphosphonate based diagnostic tool for the detection of hydroxyapatite in both cell and tissue models
Hulme, A. (Creator), Cui lin, L. (Creator), Sim, A. (Creator), Rashdan, N. (Creator), Moss, A. J. (Creator), Nudelman, F. (Creator), Dweck, M. (Creator) & MacRae, V. (Creator), Edinburgh DataShare, 9 Nov 2018