A novel mechanism for hypofibrinolysis in diabetes: the role of complement C3

K Hess; S H Alzahrani; M Mathai; V Schroeder; A M Carter; G Howell; T Koko; M W J Strachan; J F Price; K A Smith; P J Grant; R A Ajjan

doi:10.1007/s00125-011-2301-7

A novel mechanism for hypofibrinolysis in diabetes: the role of complement C3

K Hess, S H Alzahrani, M Mathai, V Schroeder, A M Carter, G Howell, T Koko, M W J Strachan, J F Price, K A Smith, P J Grant, R A Ajjan

Research output: Contribution to journal › Article › peer-review

Abstract

Impaired fibrin clot lysis is a key abnormality in diabetes and complement C3 is one protein identified in blood clots. This work investigates the mechanistic pathways linking C3 and hypofibrinolysis in diabetes using ex vivo/in vitro studies.

Original language	English
Pages (from-to)	1103-13
Number of pages	11
Journal	Diabetologia
Volume	55
Issue number	4
DOIs	https://doi.org/10.1007/s00125-011-2301-7
Publication status	Published - 2012

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title = "A novel mechanism for hypofibrinolysis in diabetes: the role of complement C3",

abstract = "Impaired fibrin clot lysis is a key abnormality in diabetes and complement C3 is one protein identified in blood clots. This work investigates the mechanistic pathways linking C3 and hypofibrinolysis in diabetes using ex vivo/in vitro studies.",

author = "K Hess and Alzahrani, {S H} and M Mathai and V Schroeder and Carter, {A M} and G Howell and T Koko and Strachan, {M W J} and Price, {J F} and Smith, {K A} and Grant, {P J} and Ajjan, {R A}",

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AU - Hess, K

AU - Alzahrani, S H

AU - Mathai, M

AU - Schroeder, V

AU - Carter, A M

AU - Howell, G

AU - Koko, T

AU - Strachan, M W J

AU - Price, J F

AU - Smith, K A

AU - Grant, P J

AU - Ajjan, R A

PY - 2012

Y1 - 2012

N2 - Impaired fibrin clot lysis is a key abnormality in diabetes and complement C3 is one protein identified in blood clots. This work investigates the mechanistic pathways linking C3 and hypofibrinolysis in diabetes using ex vivo/in vitro studies.

AB - Impaired fibrin clot lysis is a key abnormality in diabetes and complement C3 is one protein identified in blood clots. This work investigates the mechanistic pathways linking C3 and hypofibrinolysis in diabetes using ex vivo/in vitro studies.

U2 - 10.1007/s00125-011-2301-7

DO - 10.1007/s00125-011-2301-7

M3 - Article

C2 - 21918806

SN - 1432-0428

VL - 55

SP - 1103

EP - 1113

JO - Diabetologia

JF - Diabetologia

IS - 4

ER -

A novel mechanism for hypofibrinolysis in diabetes: the role of complement C3

Abstract

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