A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide

Research output: Contribution to journalArticlepeer-review

Abstract

Studies have shown that beta defensins are present in the human airways and may be relevant to the pathogenesis of cystic fibrosis lung disease. Here we report the identification of a novel mouse gene, Defb2, which shows sequence similarity to previously described mouse and human airway beta defensins. Defb2 does not appear to be expressed in the airways of untreated mice but it is upregulated in response to lipopolysaccharide. The induced expression of this gene by an inflammatory stimulus strongly suggests that this defensin contributes to host defence at the mucosal surface of the airways.

Original languageEnglish
Pages (from-to)112-6
Number of pages5
JournalFEBS Letters
Volume442
Issue number1
Publication statusPublished - 8 Jan 1999

Keywords

  • Amino Acid Sequence
  • Animals
  • Antimicrobial Cationic Peptides
  • Base Sequence
  • DNA Primers
  • DNA, Complementary
  • Defensins
  • Female
  • Humans
  • Lipopolysaccharides
  • Mice
  • Molecular Sequence Data
  • Peptides
  • Proteins
  • RNA, Messenger
  • Respiratory System
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Tissue Distribution
  • Tumor Necrosis Factor-alpha
  • Up-Regulation
  • beta-Defensins

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