A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease

Peter Holmans, Valentina Moskvina, Lesley Jones, Manu Sharma, Alexey Vedernikov, Finja Buchel, Mohamad Sadd, Jose M Bras, Francesco Bettella, Nayia Nicolaou, Javier Simón-Sánchez, Florian Mittag, J Raphael Gibbs, Claudia Schulte, Alexandra Durr, Rita Guerreiro, Dena Hernandez, Alexis Brice, Hreinn Stefánsson, Kari MajamaaThomas Gasser, Peter Heutink, Nicholas W Wood, Maria Martinez, Andrew B Singleton, Michael A Nalls, John Hardy, Huw R Morris, Nigel M Williams, International Parkinson's Disease Genomics Consortium, Colin Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease affecting 1-2% in people >60 and 3-4% in people >80. Genome-wide association (GWA) studies have now implicated significant evidence for association in at least 18 genomic regions. We have studied a large PD-meta analysis and identified a significant excess of SNPs (P
Original languageEnglish
Pages (from-to)1039-49
Number of pages11
JournalHuman Molecular Genetics
Volume22
Issue number5
DOIs
Publication statusPublished - 1 Mar 2013

Keywords

  • Alleles
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • HLA Antigens
  • Humans
  • Metabolic Networks and Pathways
  • Parkinson Disease
  • Polymorphism, Single Nucleotide
  • Risk

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