A phase I study of the trinuclear platinum compound, BBR 3464, in combination with protracted venous infusional 5-fluorouracil in patients with advanced cancer

Charlie Gourley; James Cassidy; Chris Edwards; Leslie Samuel; Donald Bisset; Gabriella Camboni; Anne Young; Dorothy Boyle; Duncan Jodrell

doi:10.1007/s00280-003-0721-x

A phase I study of the trinuclear platinum compound, BBR 3464, in combination with protracted venous infusional 5-fluorouracil in patients with advanced cancer

Charlie Gourley
, James Cassidy
, Chris Edwards
, Leslie Samuel
, Donald Bisset
, Gabriella Camboni
, Anne Young
, Dorothy Boyle
, Duncan Jodrell

Research output: Contribution to journal › Article › peer-review

Abstract

BBR 3464 is a novel trinuclear platinum anticancer agent with a broad spectrum of preclinical antitumour activity. A phase I, open-label dose-escalating study was performed to determine the maximum tolerated dose (MTD) of BBR 3464 administered in combination with protracted venous infusional (PVI) 5-fluorouracil (5-FU) for up to six courses in patients with locally advanced and/or metastatic cancer.

Original language	English
Pages (from-to)	95-101
Number of pages	7
Journal	Cancer chemotherapy and pharmacology
Volume	53
Issue number	2
DOIs	https://doi.org/10.1007/s00280-003-0721-x
Publication status	Published - Feb 2004

Keywords / Materials (for Non-textual outputs)

Adult
Aged
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Diarrhea
Fatigue
Female
Fluorouracil
Hematologic Diseases
Humans
Male
Maximum Tolerated Dose
Middle Aged
Nausea
Neoplasms
Organoplatinum Compounds

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10.1007/s00280-003-0721-x

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Gourley, C., Cassidy, J., Edwards, C., Samuel, L., Bisset, D., Camboni, G., Young, A., Boyle, D., & Jodrell, D. (2004). A phase I study of the trinuclear platinum compound, BBR 3464, in combination with protracted venous infusional 5-fluorouracil in patients with advanced cancer. Cancer chemotherapy and pharmacology, 53(2), 95-101. https://doi.org/10.1007/s00280-003-0721-x

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title = "A phase I study of the trinuclear platinum compound, BBR 3464, in combination with protracted venous infusional 5-fluorouracil in patients with advanced cancer",

abstract = "BBR 3464 is a novel trinuclear platinum anticancer agent with a broad spectrum of preclinical antitumour activity. A phase I, open-label dose-escalating study was performed to determine the maximum tolerated dose (MTD) of BBR 3464 administered in combination with protracted venous infusional (PVI) 5-fluorouracil (5-FU) for up to six courses in patients with locally advanced and/or metastatic cancer.",

keywords = "Adult, Aged, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Diarrhea, Fatigue, Female, Fluorouracil, Hematologic Diseases, Humans, Male, Maximum Tolerated Dose, Middle Aged, Nausea, Neoplasms, Organoplatinum Compounds",

author = "Charlie Gourley and James Cassidy and Chris Edwards and Leslie Samuel and Donald Bisset and Gabriella Camboni and Anne Young and Dorothy Boyle and Duncan Jodrell",

year = "2004",

month = feb,

doi = "10.1007/s00280-003-0721-x",

language = "English",

volume = "53",

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journal = "Cancer chemotherapy and pharmacology",

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Gourley, C, Cassidy, J, Edwards, C, Samuel, L, Bisset, D, Camboni, G, Young, A, Boyle, D & Jodrell, D 2004, 'A phase I study of the trinuclear platinum compound, BBR 3464, in combination with protracted venous infusional 5-fluorouracil in patients with advanced cancer', Cancer chemotherapy and pharmacology, vol. 53, no. 2, pp. 95-101. https://doi.org/10.1007/s00280-003-0721-x

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T1 - A phase I study of the trinuclear platinum compound, BBR 3464, in combination with protracted venous infusional 5-fluorouracil in patients with advanced cancer

AU - Gourley, Charlie

AU - Cassidy, James

AU - Edwards, Chris

AU - Samuel, Leslie

AU - Bisset, Donald

AU - Camboni, Gabriella

AU - Young, Anne

AU - Boyle, Dorothy

AU - Jodrell, Duncan

PY - 2004/2

Y1 - 2004/2

N2 - BBR 3464 is a novel trinuclear platinum anticancer agent with a broad spectrum of preclinical antitumour activity. A phase I, open-label dose-escalating study was performed to determine the maximum tolerated dose (MTD) of BBR 3464 administered in combination with protracted venous infusional (PVI) 5-fluorouracil (5-FU) for up to six courses in patients with locally advanced and/or metastatic cancer.

AB - BBR 3464 is a novel trinuclear platinum anticancer agent with a broad spectrum of preclinical antitumour activity. A phase I, open-label dose-escalating study was performed to determine the maximum tolerated dose (MTD) of BBR 3464 administered in combination with protracted venous infusional (PVI) 5-fluorouracil (5-FU) for up to six courses in patients with locally advanced and/or metastatic cancer.

KW - Adult

KW - Aged

KW - Antineoplastic Agents

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Diarrhea

KW - Fatigue

KW - Female

KW - Fluorouracil

KW - Hematologic Diseases

KW - Humans

KW - Male

KW - Maximum Tolerated Dose

KW - Middle Aged

KW - Nausea

KW - Neoplasms

KW - Organoplatinum Compounds

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DO - 10.1007/s00280-003-0721-x

M3 - Article

C2 - 14605864

SN - 0344-5704

VL - 53

SP - 95

EP - 101

JO - Cancer chemotherapy and pharmacology

JF - Cancer chemotherapy and pharmacology

IS - 2

ER -

A phase I study of the trinuclear platinum compound, BBR 3464, in combination with protracted venous infusional 5-fluorouracil in patients with advanced cancer

Abstract

Keywords / Materials (for Non-textual outputs)

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