A pilot study of facial, cranial and brain MRI morphometry in men with schizophrenia: Part 2

Karin Maria Henriksson, Karin Wickstrom, Nils Maltesson, Anders Ericsson, Johan Karlsson, Finn Lindgren, Kalle Astrom, Thomas Farrell McNeil, Ingrid Agartz

Research output: Contribution to journalArticlepeer-review

Abstract

This pilot study applies a new 3D morphometric MR method to test the hypothesis that men with schizophrenia (vs. controls) have deviant facial shapes and landmark relations in cranio/facial/brain (CFB) regions. This constitutes Part 2 of paired articles in this issue of Psychiatry Research: Neuroimaging, in which Part 1 presents the new method in detail. MRI coordinates from CFB landmarks of 23 patients and 15 controls were identified and then aligned with the Procrustes model, leaving shape as the only unit-less geometrical information. Men with schizophrenia had significantly longer mid- and lower-facial heights, and greater lower (left) facial depth, with a tendency toward rotation along the facial midline. This supports findings from earlier anthropometric and 3D studies of the "exterior" (face). In contrast, none of the patient-control differences for the new "interior" (cranial-brain) distances reached statistical significance. These results need to be retested on a larger sample of both sexes.

Original languageEnglish
Pages (from-to)187-195
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume147
Issue number2-3
DOIs
Publication statusPublished - 30 Oct 2006

Keywords

  • Cranio-facial landmarks
  • Magnetic resonance imaging
  • Morphometry
  • Schizophrenia
  • Shape

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