TY - JOUR
T1 - A pilot study of facial, cranial and brain MRI morphometry in men with schizophrenia
T2 - Part 2
AU - Henriksson, Karin Maria
AU - Wickstrom, Karin
AU - Maltesson, Nils
AU - Ericsson, Anders
AU - Karlsson, Johan
AU - Lindgren, Finn
AU - Astrom, Kalle
AU - McNeil, Thomas Farrell
AU - Agartz, Ingrid
N1 - Funding Information:
This study was supported by grants from the Stanley Medical Research Institute, USA (Grant No. 98-313), the Swedish Medical Research Council (Grant Nos. 3793 and 5845), and the Medical Faculty of Lund University, Sweden. We are not aware of any relationships that might lead to a conflict of interest. The participating subjects and psychiatrist Erik Jönsson, who did the clinical subject evaluation, are thanked for valuable help.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/10/30
Y1 - 2006/10/30
N2 - This pilot study applies a new 3D morphometric MR method to test the hypothesis that men with schizophrenia (vs. controls) have deviant facial shapes and landmark relations in cranio/facial/brain (CFB) regions. This constitutes Part 2 of paired articles in this issue of Psychiatry Research: Neuroimaging, in which Part 1 presents the new method in detail. MRI coordinates from CFB landmarks of 23 patients and 15 controls were identified and then aligned with the Procrustes model, leaving shape as the only unit-less geometrical information. Men with schizophrenia had significantly longer mid- and lower-facial heights, and greater lower (left) facial depth, with a tendency toward rotation along the facial midline. This supports findings from earlier anthropometric and 3D studies of the "exterior" (face). In contrast, none of the patient-control differences for the new "interior" (cranial-brain) distances reached statistical significance. These results need to be retested on a larger sample of both sexes.
AB - This pilot study applies a new 3D morphometric MR method to test the hypothesis that men with schizophrenia (vs. controls) have deviant facial shapes and landmark relations in cranio/facial/brain (CFB) regions. This constitutes Part 2 of paired articles in this issue of Psychiatry Research: Neuroimaging, in which Part 1 presents the new method in detail. MRI coordinates from CFB landmarks of 23 patients and 15 controls were identified and then aligned with the Procrustes model, leaving shape as the only unit-less geometrical information. Men with schizophrenia had significantly longer mid- and lower-facial heights, and greater lower (left) facial depth, with a tendency toward rotation along the facial midline. This supports findings from earlier anthropometric and 3D studies of the "exterior" (face). In contrast, none of the patient-control differences for the new "interior" (cranial-brain) distances reached statistical significance. These results need to be retested on a larger sample of both sexes.
KW - Cranio-facial landmarks
KW - Magnetic resonance imaging
KW - Morphometry
KW - Schizophrenia
KW - Shape
UR - https://www.scopus.com/pages/publications/33748858507
U2 - 10.1016/j.pscychresns.2006.03.004
DO - 10.1016/j.pscychresns.2006.03.004
M3 - Article
C2 - 16949799
AN - SCOPUS:33748858507
SN - 0925-4927
VL - 147
SP - 187
EP - 195
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 2-3
ER -