A PILOT-STUDY OF INDOCYANINE GREEN CLEARANCE AS AN EARLY PREDICTOR OF GRAFT FUNCTION

R JALAN*, JN PLEVRIS, AR JALAN, NDC FINLAYSON, PC HAYES, John Plevris

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Primary graft dysfunction occurs in up to 10% of liver transplant recipients and is the major reason for early mortality and retransplantation. The conventionally used markers of early graft function-i.e., correction of acidosis, glucose requirement, consumption of potassium, serum alanine transaminase (ALT),* prothrombin time (PT), bile flow, resolution of encephalopathy and haemodynamic instability can be very misleading as they are dependent on numerous other factors. The aim of this study was to assess the use of indocyanine green clearance (ICG) as a measure of graft function.

Peripheral ICG clearance was measured 18-24 hr after liver transplantation in twenty-three consecutive patients (24 transplants). Doppler ultrasonography confirmed normal hepatic arterial blood flow. Correlations between ICG clearance and other markers of graft function and outcome were sought.

The mean ICG clearance was 406 mls/min (SD 137.5). A threshold value of 200 ml/min reliably predicted outcome. Significant correlations were found between ICG clearance and times to normalization of PT (P

ICG clearance measured on the day after liver transplantation accurately reflects graft function and may be used to predict graft survival and final outcome.

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalTransplantation
Volume58
Issue number2
Publication statusPublished - 27 Jul 1994

Keywords / Materials (for Non-textual outputs)

  • LIVER-TRANSPLANTATION
  • INDICATORS
  • INJURY

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