A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients

D C McMillan, P O'Gorman, K C Fearon, C S McArdle

Research output: Contribution to journalArticlepeer-review

Abstract

Advanced gastrointestinal cancer patients with weight loss and an acute-phase response (n = 15) were given megestrol acetate (480 mg day(-1)) and ibuprofen (1200 mg day(-1)) for 6 weeks. Overall, there was an increase in body weight (P = 0.01) and a reduction in C-reactive protein concentrations (P = 0.02), with no change in total body water (P = 0.24) over this period. This regimen may be an effective non-toxic treatment for cancer cachexia and is worthy of further study.
Original languageEnglish
Pages (from-to)788-90
Number of pages3
JournalBritish Journal of Cancer
Volume76
Issue number6
Publication statusPublished - 1997

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