A Pooled Genome-Wide Association Study of Asperger Syndrome

Varun Warrier, Bhismadev Chakrabarti, Laura Murphy, Allen Chan, Ian Craig, Uma Mallya, Silvia Lakatošová, Karola Rehnstrom, Leena Peltonen, Sally Wheelwright, Carrie Allison, Simon E Fisher, Simon Baron-Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Asperger Syndrome (AS) is a neurodevelopmental condition characterized by impairments in social interaction and communication, alongside the presence of unusually repetitive, restricted interests and stereotyped behaviour. Individuals with AS have no delay in cognitive and language development. It is a subset of Autism Spectrum Conditions (ASC), which are highly heritable and has a population prevalence of approximately 1%. Few studies have investigated the genetic basis of AS. To address this gap in the literature, we performed a genome-wide pooled DNA association study to identify candidate loci in 612 individuals (294 cases and 318 controls) of Caucasian ancestry, using the Affymetrix GeneChip Human Mapping version 6.0 array. We identified 11 SNPs that had a p-value below 1x10-5. These SNPs were independently genotyped in the same sample. Three of the SNPs (rs1268055, rs7785891 and rs2782448) were nominally significant, though none remained significant after Bonferroni correction. Two of our top three SNPs (rs7785891 and rs2782448) lie in loci previously implicated in ASC. However, investigation of the three SNPs in the ASC genome-wide association dataset from the Psychiatric Genomics Consortium indicated that these three SNPs were not significantly associated with ASC. The effect sizes of the variants were modest, indicating that our study was not sufficiently powered to identify causal variants with precision.

Original languageEnglish
Pages (from-to)e0131202
JournalPLoS ONE
Volume10
Issue number7
DOIs
Publication statusPublished - 2015

Keywords

  • Asperger Syndrome
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genome, Human
  • Genome-Wide Association Study
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Journal Article
  • Research Support, Non-U.S. Gov't

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