Positron emission tomography (PET) was used to investigate the location of cerebral cortical and subcortical abnormalities in non-demented patients with amyotrophic lateral sclerosis (ALS). Involvement of the frontal lobes was investigated with a task of executive frontal lobe function (verbal fluency/word generation), using a PET activation paradigm. Two groups of ALS patients defined by the presence or absence of cognitive impairment were tested. ALS patients who had cognitive impairments showed a region of cortical and subcortical dysfunction which extended across a wide area of the frontal lobes, and included the insular cortex and thalamic nuclear complex. These findings support the notion that extra-motor involvement is relatively common in ALS and broadens concepts of selective vulnerability in ALS.
|Number of pages||3|
|Journal||Journal of the Neurological Sciences|
|Publication status||Published - May 1995|
- AMYOTROPHIC LATERAL SCLEROSIS
- POSITRON EMISSION TOMOGRAPHY
- FRONTAL LOBES
- MOTOR NEURON DISEASE