Projects per year
Abstract / Description of output
It is often unclear what specific adaptive trial design features lead to an efficient design which is also feasible to implement. Before deciding on a particular design, it is generally advisable to carry out a simulation study to characterise the properties of candidate designs under a range of plausible assumptions. The implementation of such pre‐trial simulation studies presents many challenges and requires considerable statistical programming effort and time. Despite the scale and complexity, there is little existing literature to guide the implementation of such projects using commonly available software. This Teacher's Corner article provides a practical step‐by‐step guide to implementing such simulation studies including how to specify and fit a Bayesian model in WinBUGS or OpenBUGS using SAS, and how results from the Bayesian analysis may be pulled back into SAS and used for adaptation of allocation probabilities before simulating subsequent stages of the trial. The interface between the two software platforms is described in detail along with useful tips and tricks. A key strength of our approach is that the entire exercise can be defined and controlled from within a single SAS program.
Original language | English |
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Journal | Pharmaceutical Statistics |
Early online date | 14 Sept 2018 |
DOIs | |
Publication status | E-pub ahead of print - 14 Sept 2018 |
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Dive into the research topics of 'A practical guide to pre-trial simulations for Bayesian adaptive trials using SAS and BUGS'. Together they form a unique fingerprint.Projects
- 2 Finished
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Development Clinical Studies: Reversing endometial glucocorticoid deficiency in heavy menstrual bleeding
Critchley, H., Hillier, S., Ireland, J., Saunders, P., Semple, C., Walker, B., Warner, P. & Weir, C.
1/12/12 → 30/11/17
Project: Research
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Development Clinical Studies - Reversing endometial glucocorticoid deficiency in heavy menstrual bleeding
1/12/12 → 31/05/18
Project: Research
Profiles
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Pam Warner
- Deanery of Molecular, Genetic and Population Health Sciences - UoE Honorary staff
Person: Affiliated Independent Researcher