A Randomised Controlled Trial Evaluating a Rehabilitation Complex Intervention for patients following Intensive Care discharge: the RECOVER study

Timothy Walsh; Lisa Salisbury; Julia Boyd; Pam Ramsay; J. L. Merriweather; Guro Huby; John Forbes; Janice Rattray; David Griffith; Simon J. Mackenzie; Alastair Hull; Stephanie Lewis; Gordon Murray

doi:10.1136/bmjopen-2012-001475

A Randomised Controlled Trial Evaluating a Rehabilitation Complex Intervention for patients following Intensive Care discharge: the RECOVER study

Timothy Walsh, Lisa Salisbury, Julia Boyd, Pam Ramsay, J. L. Merriweather, Guro Huby, John Forbes, Janice Rattray, David Griffith, Simon J. Mackenzie, Alastair Hull, Stephanie Lewis, Gordon Murray

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Introduction
Patients who survive an intensive care unit (ICU) admission frequently suffer physical and psychological morbidity for many months after discharge. Current rehabilitation pathways are often fragmented and little is known about the optimum method of promoting recovery. Many patients suffer reduced quality of life.
Methods and analysis
We plan a multicentre randomised parallel group complex intervention trial with concealment of group allocation from outcome assessors. Patients who required more than 48 hours of mechanical ventilation and are deemed fit for ICU discharge will be eligible. Patients with primary neurological diagnoses will be excluded. Participants will be randomised into one of two groups: the intervention group will receive standard ward-based care delivered by the NHS service with additional treatment by a specifically trained generic rehabilitation assistant during ward stay and via telephone contact after hospital discharge; the control group will receive standard ward-based care delivered by the current NHS service. The intervention group will also receive additional information about their critical illness and access to a critical care physician. The total duration of the intervention will be from randomisation to 3 months post-randomisation. The total duration of follow-up will be 12 months from randomisation for both groups. The primary outcome will be the Rivermead Mobility Index at 3 months. Secondary outcomes will include measures of physical and psychological morbidity and function, quality of life, and survival over a 12 month period. A health economic evaluation will also be undertaken. Groups will be compared in relation to primary and secondary outcomes; quantitative analyses will be supplemented by focus groups with patients, carers, and healthcare workers.
Ethics and dissemination
Consent will be obtained from patients and relatives according to patient capacity. Data will be analysed according to a pre-defined analysis plan
Trial Registration
The trial is registered as ISRCTN09412438 and funded by the Chief Scientist Office, Scotland.

Original language	English
Article number	e001475
Journal	BMJ Open
Volume	2
Issue number	4
DOIs	https://doi.org/10.1136/bmjopen-2012-001475
Publication status	Published - 2012

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A Randomised Controlled Trial Evaluating a Rehabilitation Complex Intervention for patients following Intensive Care discharge
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http://bmjopen.bmj.com/content/2/4/e001475

3 Article
1 Letter

The Burden of Specific Symptoms Reported by Survivors After Critical Illness
Griffith, D. M., Salisbury, L., Lee, R. J., Lone, N., Merriweather, J. L. & Walsh, T. S., 15 Jan 2018, In: American Journal of Respiratory and Critical Care Medicine. 197, 2, p. 269-272 4 p.
Research output: Contribution to journal › Letter › peer-review

Open Access
File
Patient and carer experience of hospital based rehabilitation from Intensive Care to hospital discharge: mixed methods process evaluation of the RECOVER randomised clinical trial
Ramsay, P., Huby, G., Merriweather, J. L., Griffith, D. & Walsh, T., 1 Aug 2016, In: BMJ Open. 6, 8, p. e012041
Research output: Contribution to journal › Article › peer-review

Open Access
File
Systemic inflammation after critical illness: relationship with physical recovery and exploration of potential mechanisms
RECOVER Investigators, Griffith, D. M., Lewis, S., Rossi, A. G., Rennie, J., Salisbury, L., Merriweather, J. L., Templeton, K. & Walsh, T. S., 26 Apr 2016, In: Thorax. 71, 9, p. 820-829 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File

Cite this

Walsh, T., Salisbury, L., Boyd, J., Ramsay, P., Merriweather, J. L., Huby, G., Forbes, J., Rattray, J., Griffith, D., Mackenzie, S. J., Hull, A., Lewis, S., & Murray, G. (2012). A Randomised Controlled Trial Evaluating a Rehabilitation Complex Intervention for patients following Intensive Care discharge: the RECOVER study. BMJ Open, 2(4), Article e001475. https://doi.org/10.1136/bmjopen-2012-001475

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title = "A Randomised Controlled Trial Evaluating a Rehabilitation Complex Intervention for patients following Intensive Care discharge: the RECOVER study",

abstract = "Introduction Patients who survive an intensive care unit (ICU) admission frequently suffer physical and psychological morbidity for many months after discharge. Current rehabilitation pathways are often fragmented and little is known about the optimum method of promoting recovery. Many patients suffer reduced quality of life. Methods and analysis We plan a multicentre randomised parallel group complex intervention trial with concealment of group allocation from outcome assessors. Patients who required more than 48 hours of mechanical ventilation and are deemed fit for ICU discharge will be eligible. Patients with primary neurological diagnoses will be excluded. Participants will be randomised into one of two groups: the intervention group will receive standard ward-based care delivered by the NHS service with additional treatment by a specifically trained generic rehabilitation assistant during ward stay and via telephone contact after hospital discharge; the control group will receive standard ward-based care delivered by the current NHS service. The intervention group will also receive additional information about their critical illness and access to a critical care physician. The total duration of the intervention will be from randomisation to 3 months post-randomisation. The total duration of follow-up will be 12 months from randomisation for both groups. The primary outcome will be the Rivermead Mobility Index at 3 months. Secondary outcomes will include measures of physical and psychological morbidity and function, quality of life, and survival over a 12 month period. A health economic evaluation will also be undertaken. Groups will be compared in relation to primary and secondary outcomes; quantitative analyses will be supplemented by focus groups with patients, carers, and healthcare workers. Ethics and dissemination Consent will be obtained from patients and relatives according to patient capacity. Data will be analysed according to a pre-defined analysis plan Trial Registration The trial is registered as ISRCTN09412438 and funded by the Chief Scientist Office, Scotland.",

author = "Timothy Walsh and Lisa Salisbury and Julia Boyd and Pam Ramsay and Merriweather, {J. L.} and Guro Huby and John Forbes and Janice Rattray and David Griffith and Mackenzie, {Simon J.} and Alastair Hull and Stephanie Lewis and Gordon Murray",

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doi = "10.1136/bmjopen-2012-001475",

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Walsh, T, Salisbury, L, Boyd, J, Ramsay, P, Merriweather, JL, Huby, G, Forbes, J, Rattray, J, Griffith, D, Mackenzie, SJ, Hull, A, Lewis, S & Murray, G 2012, 'A Randomised Controlled Trial Evaluating a Rehabilitation Complex Intervention for patients following Intensive Care discharge: the RECOVER study', BMJ Open, vol. 2, no. 4, e001475. https://doi.org/10.1136/bmjopen-2012-001475

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T1 - A Randomised Controlled Trial Evaluating a Rehabilitation Complex Intervention for patients following Intensive Care discharge

T2 - the RECOVER study

AU - Walsh, Timothy

AU - Salisbury, Lisa

AU - Boyd, Julia

AU - Ramsay, Pam

AU - Merriweather, J. L.

AU - Huby, Guro

AU - Forbes, John

AU - Rattray, Janice

AU - Griffith, David

AU - Mackenzie, Simon J.

AU - Hull, Alastair

AU - Lewis, Stephanie

AU - Murray, Gordon

PY - 2012

Y1 - 2012

N2 - Introduction Patients who survive an intensive care unit (ICU) admission frequently suffer physical and psychological morbidity for many months after discharge. Current rehabilitation pathways are often fragmented and little is known about the optimum method of promoting recovery. Many patients suffer reduced quality of life. Methods and analysis We plan a multicentre randomised parallel group complex intervention trial with concealment of group allocation from outcome assessors. Patients who required more than 48 hours of mechanical ventilation and are deemed fit for ICU discharge will be eligible. Patients with primary neurological diagnoses will be excluded. Participants will be randomised into one of two groups: the intervention group will receive standard ward-based care delivered by the NHS service with additional treatment by a specifically trained generic rehabilitation assistant during ward stay and via telephone contact after hospital discharge; the control group will receive standard ward-based care delivered by the current NHS service. The intervention group will also receive additional information about their critical illness and access to a critical care physician. The total duration of the intervention will be from randomisation to 3 months post-randomisation. The total duration of follow-up will be 12 months from randomisation for both groups. The primary outcome will be the Rivermead Mobility Index at 3 months. Secondary outcomes will include measures of physical and psychological morbidity and function, quality of life, and survival over a 12 month period. A health economic evaluation will also be undertaken. Groups will be compared in relation to primary and secondary outcomes; quantitative analyses will be supplemented by focus groups with patients, carers, and healthcare workers. Ethics and dissemination Consent will be obtained from patients and relatives according to patient capacity. Data will be analysed according to a pre-defined analysis plan Trial Registration The trial is registered as ISRCTN09412438 and funded by the Chief Scientist Office, Scotland.

AB - Introduction Patients who survive an intensive care unit (ICU) admission frequently suffer physical and psychological morbidity for many months after discharge. Current rehabilitation pathways are often fragmented and little is known about the optimum method of promoting recovery. Many patients suffer reduced quality of life. Methods and analysis We plan a multicentre randomised parallel group complex intervention trial with concealment of group allocation from outcome assessors. Patients who required more than 48 hours of mechanical ventilation and are deemed fit for ICU discharge will be eligible. Patients with primary neurological diagnoses will be excluded. Participants will be randomised into one of two groups: the intervention group will receive standard ward-based care delivered by the NHS service with additional treatment by a specifically trained generic rehabilitation assistant during ward stay and via telephone contact after hospital discharge; the control group will receive standard ward-based care delivered by the current NHS service. The intervention group will also receive additional information about their critical illness and access to a critical care physician. The total duration of the intervention will be from randomisation to 3 months post-randomisation. The total duration of follow-up will be 12 months from randomisation for both groups. The primary outcome will be the Rivermead Mobility Index at 3 months. Secondary outcomes will include measures of physical and psychological morbidity and function, quality of life, and survival over a 12 month period. A health economic evaluation will also be undertaken. Groups will be compared in relation to primary and secondary outcomes; quantitative analyses will be supplemented by focus groups with patients, carers, and healthcare workers. Ethics and dissemination Consent will be obtained from patients and relatives according to patient capacity. Data will be analysed according to a pre-defined analysis plan Trial Registration The trial is registered as ISRCTN09412438 and funded by the Chief Scientist Office, Scotland.

U2 - 10.1136/bmjopen-2012-001475

DO - 10.1136/bmjopen-2012-001475

M3 - Article

C2 - 22761291

SN - 2044-6055

VL - 2

JO - BMJ Open

JF - BMJ Open

IS - 4

M1 - e001475

ER -

A Randomised Controlled Trial Evaluating a Rehabilitation Complex Intervention for patients following Intensive Care discharge: the RECOVER study

Abstract / Description of output

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Research output

The Burden of Specific Symptoms Reported by Survivors After Critical Illness

Patient and carer experience of hospital based rehabilitation from Intensive Care to hospital discharge: mixed methods process evaluation of the RECOVER randomised clinical trial

Systemic inflammation after critical illness: relationship with physical recovery and exploration of potential mechanisms

Cite this