A randomized cross-over study of the metabolic and hormonal responses following two preoperative conditioning drinks

Sherif Awad; Kenneth C H Fearon; Ian A Macdonald; Dileep N Lobo

doi:10.1016/j.nut.2010.08.025

A randomized cross-over study of the metabolic and hormonal responses following two preoperative conditioning drinks

Sherif Awad, Kenneth C H Fearon, Ian A Macdonald, Dileep N Lobo

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Preoperative conditioning with carbohydrate-based drinks attenuates postoperative insulin resistance and leads to clinical benefits. The use of metabolic conditioning agents such as glutamine and antioxidants, in addition to carbohydrate, may benefit patients undergoing major surgery, because glutamine and antioxidant supplementation have been shown to improve gastrointestinal perfusion, immune function, morbidity, and gluco-metabolic control in critically ill patients. We investigated the postprandial responses after ingestion of a clear carbohydrate drink (CCD) containing 50 g of carbohydrate (preOp, Nutricia, Trowbridge, UK) and that of another drink containing 50 g of carbohydrate, 15 g of glutamine, and antioxidants (ONS; Fresenius Kabi, Bad Homburg, Germany).

Original language	English
Pages (from-to)	938-42
Number of pages	5
Journal	Nutrition
Volume	27
Issue number	9
DOIs	https://doi.org/10.1016/j.nut.2010.08.025
Publication status	Published - 2011

Keywords

Adolescent
Adult
Antioxidants
Beverages
Blood Glucose
Body Mass Index
Cross-Over Studies
Dietary Carbohydrates
Double-Blind Method
Fasting
Glutamine
Humans
Insulin
Male
Postprandial Period
Preoperative Care
Young Adult

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10.1016/j.nut.2010.08.025

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title = "A randomized cross-over study of the metabolic and hormonal responses following two preoperative conditioning drinks",

abstract = "Preoperative conditioning with carbohydrate-based drinks attenuates postoperative insulin resistance and leads to clinical benefits. The use of metabolic conditioning agents such as glutamine and antioxidants, in addition to carbohydrate, may benefit patients undergoing major surgery, because glutamine and antioxidant supplementation have been shown to improve gastrointestinal perfusion, immune function, morbidity, and gluco-metabolic control in critically ill patients. We investigated the postprandial responses after ingestion of a clear carbohydrate drink (CCD) containing 50 g of carbohydrate (preOp, Nutricia, Trowbridge, UK) and that of another drink containing 50 g of carbohydrate, 15 g of glutamine, and antioxidants (ONS; Fresenius Kabi, Bad Homburg, Germany).",

keywords = "Adolescent, Adult, Antioxidants, Beverages, Blood Glucose, Body Mass Index, Cross-Over Studies, Dietary Carbohydrates, Double-Blind Method, Fasting, Glutamine, Humans, Insulin, Male, Postprandial Period, Preoperative Care, Young Adult",

author = "Sherif Awad and Fearon, {Kenneth C H} and Macdonald, {Ian A} and Lobo, {Dileep N}",

year = "2011",

doi = "10.1016/j.nut.2010.08.025",

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journal = "Nutrition",

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AU - Fearon, Kenneth C H

AU - Macdonald, Ian A

AU - Lobo, Dileep N

PY - 2011

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AB - Preoperative conditioning with carbohydrate-based drinks attenuates postoperative insulin resistance and leads to clinical benefits. The use of metabolic conditioning agents such as glutamine and antioxidants, in addition to carbohydrate, may benefit patients undergoing major surgery, because glutamine and antioxidant supplementation have been shown to improve gastrointestinal perfusion, immune function, morbidity, and gluco-metabolic control in critically ill patients. We investigated the postprandial responses after ingestion of a clear carbohydrate drink (CCD) containing 50 g of carbohydrate (preOp, Nutricia, Trowbridge, UK) and that of another drink containing 50 g of carbohydrate, 15 g of glutamine, and antioxidants (ONS; Fresenius Kabi, Bad Homburg, Germany).

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KW - Beverages

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KW - Body Mass Index

KW - Cross-Over Studies

KW - Dietary Carbohydrates

KW - Double-Blind Method

KW - Fasting

KW - Glutamine

KW - Humans

KW - Insulin

KW - Male

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EP - 942

JO - Nutrition

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SN - 0899-9007

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A randomized cross-over study of the metabolic and hormonal responses following two preoperative conditioning drinks

Abstract

Keywords

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