A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer

Rakesh Heer, Rebecca Lewis, Thenmalar Vadiveloo, Ge Yu, Paramananthan Mariappan, Joanne Cresswell, John McGrath, Ghulam Nabi, Hugh Mostafid, Henry Lazarowicz, John Kelly, Anne Duncan, Steven Penegar, Matt Breckons, Laura Wilson, Emma Clark, Andy Feber, Giovany Orozco-Leal, Zafer Tandogdu, Ernest TaylorJames N'Dow, John Norrie, Craig Ramsay, Stephen Rice, Luke Vale, Graeme MacLennan, Emma Hall

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

PDD or WL Resection of Tumors in NMIBCIn this open-label trial, patients with intermediate- or high-risk non-muscle-invasive bladder cancer at diagnosis were randomly assigned to photodynamic diagnosis or white light-guided transurethral resection of bladder tumor. Three-year recurrence-free rates were 57.8% and 61.6% in the PDD and WL groups, respectively, with no difference in quality-adjusted life years between the treatment groups at 3 years.

Original languageEnglish
Article numberEVIDoa2200092
JournalNEJM evidence
Issue number10
Publication statusPublished - 2 Sept 2022

Keywords / Materials (for Non-textual outputs)

  • Humans
  • Photosensitizing Agents
  • Aminolevulinic Acid
  • Non-Muscle Invasive Bladder Neoplasms
  • Urinary Bladder Neoplasms/diagnosis
  • Urologic Surgical Procedures


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