A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer

Rakesh Heer; Rebecca Lewis; Thenmalar Vadiveloo; Ge Yu; Paramananthan Mariappan; Joanne Cresswell; John McGrath; Ghulam Nabi; Hugh Mostafid; Henry Lazarowicz; John Kelly; Anne Duncan; Steven Penegar; Matt Breckons; Laura Wilson; Emma Clark; Andy Feber; Giovany Orozco-Leal; Zafer Tandogdu; Ernest Taylor; James N'Dow; John Norrie; Craig Ramsay; Stephen Rice; Luke Vale; Graeme MacLennan; Emma Hall

doi:10.1056/EVIDoa2200092

A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer

Rakesh Heer, Rebecca Lewis, Thenmalar Vadiveloo, Ge Yu, Paramananthan Mariappan, Joanne Cresswell, John McGrath, Ghulam Nabi, Hugh Mostafid, Henry Lazarowicz, John Kelly, Anne Duncan, Steven Penegar, Matt Breckons, Laura Wilson, Emma Clark, Andy Feber, Giovany Orozco-Leal, Zafer Tandogdu, Ernest TaylorJames N'Dow, John Norrie, Craig Ramsay, Stephen Rice, Luke Vale, Graeme MacLennan, Emma Hall

Research output: Contribution to journal › Article › peer-review

Abstract

PDD or WL Resection of Tumors in NMIBCIn this open-label trial, patients with intermediate- or high-risk non-muscle-invasive bladder cancer at diagnosis were randomly assigned to photodynamic diagnosis or white light-guided transurethral resection of bladder tumor. Three-year recurrence-free rates were 57.8% and 61.6% in the PDD and WL groups, respectively, with no difference in quality-adjusted life years between the treatment groups at 3 years.

Original language	English
Article number	EVIDoa2200092
Journal	NEJM evidence
Volume	1
Issue number	10
DOIs	https://doi.org/10.1056/EVIDoa2200092
Publication status	Published - 2 Sept 2022

Keywords / Materials (for Non-textual outputs)

Humans
Photosensitizing Agents
Aminolevulinic Acid
Non-Muscle Invasive Bladder Neoplasms
Urinary Bladder Neoplasms/diagnosis
Urologic Surgical Procedures

Access to Document

10.1056/EVIDoa2200092

https://repository.icr.ac.uk/handle/internal/5272?show=full

Cite this

Heer, R., Lewis, R., Vadiveloo, T., Yu, G., Mariappan, P., Cresswell, J., McGrath, J., Nabi, G., Mostafid, H., Lazarowicz, H., Kelly, J., Duncan, A., Penegar, S., Breckons, M., Wilson, L., Clark, E., Feber, A., Orozco-Leal, G., Tandogdu, Z., ... Hall, E. (2022). A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer. NEJM evidence, 1(10), Article EVIDoa2200092. https://doi.org/10.1056/EVIDoa2200092

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title = "A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer",

abstract = "PDD or WL Resection of Tumors in NMIBCIn this open-label trial, patients with intermediate- or high-risk non-muscle-invasive bladder cancer at diagnosis were randomly assigned to photodynamic diagnosis or white light-guided transurethral resection of bladder tumor. Three-year recurrence-free rates were 57.8% and 61.6% in the PDD and WL groups, respectively, with no difference in quality-adjusted life years between the treatment groups at 3 years.",

keywords = "Humans, Photosensitizing Agents, Aminolevulinic Acid, Non-Muscle Invasive Bladder Neoplasms, Urinary Bladder Neoplasms/diagnosis, Urologic Surgical Procedures",

author = "Rakesh Heer and Rebecca Lewis and Thenmalar Vadiveloo and Ge Yu and Paramananthan Mariappan and Joanne Cresswell and John McGrath and Ghulam Nabi and Hugh Mostafid and Henry Lazarowicz and John Kelly and Anne Duncan and Steven Penegar and Matt Breckons and Laura Wilson and Emma Clark and Andy Feber and Giovany Orozco-Leal and Zafer Tandogdu and Ernest Taylor and James N'Dow and John Norrie and Craig Ramsay and Stephen Rice and Luke Vale and Graeme MacLennan and Emma Hall",

year = "2022",

month = sep,

day = "2",

doi = "10.1056/EVIDoa2200092",

language = "English",

volume = "1",

journal = "NEJM evidence",

issn = "2766-5526",

publisher = "Massachussetts Medical Society",

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}

Heer, R, Lewis, R, Vadiveloo, T, Yu, G, Mariappan, P, Cresswell, J, McGrath, J, Nabi, G, Mostafid, H, Lazarowicz, H, Kelly, J, Duncan, A, Penegar, S, Breckons, M, Wilson, L, Clark, E, Feber, A, Orozco-Leal, G, Tandogdu, Z, Taylor, E, N'Dow, J, Norrie, J, Ramsay, C, Rice, S, Vale, L, MacLennan, G & Hall, E 2022, 'A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer', NEJM evidence, vol. 1, no. 10, EVIDoa2200092. https://doi.org/10.1056/EVIDoa2200092

TY - JOUR

T1 - A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer

AU - Heer, Rakesh

AU - Lewis, Rebecca

AU - Vadiveloo, Thenmalar

AU - Yu, Ge

AU - Mariappan, Paramananthan

AU - Cresswell, Joanne

AU - McGrath, John

AU - Nabi, Ghulam

AU - Mostafid, Hugh

AU - Lazarowicz, Henry

AU - Kelly, John

AU - Duncan, Anne

AU - Penegar, Steven

AU - Breckons, Matt

AU - Wilson, Laura

AU - Clark, Emma

AU - Feber, Andy

AU - Orozco-Leal, Giovany

AU - Tandogdu, Zafer

AU - Taylor, Ernest

AU - N'Dow, James

AU - Norrie, John

AU - Ramsay, Craig

AU - Rice, Stephen

AU - Vale, Luke

AU - MacLennan, Graeme

AU - Hall, Emma

PY - 2022/9/2

Y1 - 2022/9/2

N2 - PDD or WL Resection of Tumors in NMIBCIn this open-label trial, patients with intermediate- or high-risk non-muscle-invasive bladder cancer at diagnosis were randomly assigned to photodynamic diagnosis or white light-guided transurethral resection of bladder tumor. Three-year recurrence-free rates were 57.8% and 61.6% in the PDD and WL groups, respectively, with no difference in quality-adjusted life years between the treatment groups at 3 years.

AB - PDD or WL Resection of Tumors in NMIBCIn this open-label trial, patients with intermediate- or high-risk non-muscle-invasive bladder cancer at diagnosis were randomly assigned to photodynamic diagnosis or white light-guided transurethral resection of bladder tumor. Three-year recurrence-free rates were 57.8% and 61.6% in the PDD and WL groups, respectively, with no difference in quality-adjusted life years between the treatment groups at 3 years.

KW - Humans

KW - Photosensitizing Agents

KW - Aminolevulinic Acid

KW - Non-Muscle Invasive Bladder Neoplasms

KW - Urinary Bladder Neoplasms/diagnosis

KW - Urologic Surgical Procedures

U2 - 10.1056/EVIDoa2200092

DO - 10.1056/EVIDoa2200092

M3 - Article

C2 - 38319866

SN - 2766-5526

VL - 1

JO - NEJM evidence

JF - NEJM evidence

IS - 10

M1 - EVIDoa2200092

ER -

A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer

Abstract

Keywords / Materials (for Non-textual outputs)

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