A re-evaluatiou of the use of rink, BAL, and PAL resins and linkers

F Yraola; R Ventura; M Vendrell; A Colombo; JC Fernandez; N de la Figuera; D Fernandez-Forner; M Royo; P Forns; F Albericio

A re-evaluatiou of the use of rink, BAL, and PAL resins and linkers

F Yraola, R Ventura, M Vendrell, A Colombo, JC Fernandez, N de la Figuera, D Fernandez-Forner, M Royo, P Forns, F Albericio^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The preparation of amine and guanidine derivatives of phenylalaninamide and tryptophanamide as well as benzylamines from BAL, Rink-MBHA, and Rink resins has been performed. Cleavage of the target compound gave significant amounts of byproducts compounds in which the linker moiety was attached to the target unit. This side reaction can be avoided when the solid supports are prepared by anchoring the corresponding linker to an aminomethyl resin.

Original language	English
Pages (from-to)	145-152
Number of pages	8
Journal	QSAR and Combinatorial Science
Volume	23
Issue number	2-3
Publication status	Published - Apr 2004

Keywords

combinatorial chemistry
handle
AM linker
side reaction
solid-phase
SOLID-PHASE SYNTHESIS
TERMINAL PEPTIDE AMIDES
MILD CONDITIONS
COMBINATORIAL CHEMISTRY
ORGANIC-SYNTHESIS
ACID
LINKAGE
CLEAVAGE
STRATEGY
AMINES

Cite this

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title = "A re-evaluatiou of the use of rink, BAL, and PAL resins and linkers",

abstract = "The preparation of amine and guanidine derivatives of phenylalaninamide and tryptophanamide as well as benzylamines from BAL, Rink-MBHA, and Rink resins has been performed. Cleavage of the target compound gave significant amounts of byproducts compounds in which the linker moiety was attached to the target unit. This side reaction can be avoided when the solid supports are prepared by anchoring the corresponding linker to an aminomethyl resin.",

keywords = "combinatorial chemistry, handle, AM linker, side reaction, solid-phase, SOLID-PHASE SYNTHESIS, TERMINAL PEPTIDE AMIDES, MILD CONDITIONS, COMBINATORIAL CHEMISTRY, ORGANIC-SYNTHESIS, ACID, LINKAGE, CLEAVAGE, STRATEGY, AMINES",

author = "F Yraola and R Ventura and M Vendrell and A Colombo and JC Fernandez and {de la Figuera}, N and D Fernandez-Forner and M Royo and P Forns and F Albericio",

year = "2004",

month = apr,

language = "English",

volume = "23",

pages = "145--152",

journal = "QSAR and Combinatorial Science",

issn = "1611-020X",

publisher = "Wiley-VCH Verlag",

number = "2-3",

}

TY - JOUR

T1 - A re-evaluatiou of the use of rink, BAL, and PAL resins and linkers

AU - Yraola, F

AU - Ventura, R

AU - Vendrell, M

AU - Colombo, A

AU - Fernandez, JC

AU - de la Figuera, N

AU - Fernandez-Forner, D

AU - Royo, M

AU - Forns, P

AU - Albericio, F

PY - 2004/4

Y1 - 2004/4

N2 - The preparation of amine and guanidine derivatives of phenylalaninamide and tryptophanamide as well as benzylamines from BAL, Rink-MBHA, and Rink resins has been performed. Cleavage of the target compound gave significant amounts of byproducts compounds in which the linker moiety was attached to the target unit. This side reaction can be avoided when the solid supports are prepared by anchoring the corresponding linker to an aminomethyl resin.

AB - The preparation of amine and guanidine derivatives of phenylalaninamide and tryptophanamide as well as benzylamines from BAL, Rink-MBHA, and Rink resins has been performed. Cleavage of the target compound gave significant amounts of byproducts compounds in which the linker moiety was attached to the target unit. This side reaction can be avoided when the solid supports are prepared by anchoring the corresponding linker to an aminomethyl resin.

KW - combinatorial chemistry

KW - handle

KW - AM linker

KW - side reaction

KW - solid-phase

KW - SOLID-PHASE SYNTHESIS

KW - TERMINAL PEPTIDE AMIDES

KW - MILD CONDITIONS

KW - COMBINATORIAL CHEMISTRY

KW - ORGANIC-SYNTHESIS

KW - ACID

KW - LINKAGE

KW - CLEAVAGE

KW - STRATEGY

KW - AMINES

M3 - Article

VL - 23

SP - 145

EP - 152

JO - QSAR and Combinatorial Science

JF - QSAR and Combinatorial Science

SN - 1611-020X

IS - 2-3

ER -

A re-evaluatiou of the use of rink, BAL, and PAL resins and linkers

Abstract

Keywords

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