A re-evaluatiou of the use of rink, BAL, and PAL resins and linkers

F Yraola, R Ventura, M Vendrell, A Colombo, JC Fernandez, N de la Figuera, D Fernandez-Forner, M Royo, P Forns, F Albericio*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The preparation of amine and guanidine derivatives of phenylalaninamide and tryptophanamide as well as benzylamines from BAL, Rink-MBHA, and Rink resins has been performed. Cleavage of the target compound gave significant amounts of byproducts compounds in which the linker moiety was attached to the target unit. This side reaction can be avoided when the solid supports are prepared by anchoring the corresponding linker to an aminomethyl resin.

Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalQSAR and Combinatorial Science
Volume23
Issue number2-3
Publication statusPublished - Apr 2004

Keywords / Materials (for Non-textual outputs)

  • combinatorial chemistry
  • handle
  • AM linker
  • side reaction
  • solid-phase
  • SOLID-PHASE SYNTHESIS
  • TERMINAL PEPTIDE AMIDES
  • MILD CONDITIONS
  • COMBINATORIAL CHEMISTRY
  • ORGANIC-SYNTHESIS
  • ACID
  • LINKAGE
  • CLEAVAGE
  • STRATEGY
  • AMINES

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