A retrospective audit of 200 cases of CNS tumours and their surgical management in a tertiary care centre

F E Muhamat Nor, J C Marks, Chandrasekaran Kaliaperumal

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

AIMS: To study the nature of the tumours managed in the Irish population.

METHODS: This audit research was completed via a retrospective medical review on 200 patients with CNS tumours managed in a tertiary care centre between 2008 and 2009.

RESULTS: The mean age was 53 years. The male:female ratio was 2:1. The majority were glioblastomas and astrocytomas. Grade IV tumours were predominant (65.5 %). Headaches (37 %), motor weakness (32 %) and seizures (25.5 %) were the highest presentations. The commonest sites affected were the left parietal and left temporal lobes. There were 17.5 % operative morbidities with motor weakness (22.9 %), seizure (14.3 %) and thrombo-embolism (14.3 %) dominating and significant association to surgical radicality (p = 0.041). 3.5 % operative mortalities were reported. 52.5 and 62.5 % of patients received adjuvant chemotherapy and radiotherapy, respectively.

CONCLUSIONS: Patients with CNS tumours typically had multiple presentations. More extensive surgical resection was associated with higher postoperative morbidities (p = 0.041). The 30-day postoperative morbidity (17.5 %) and mortality (3.5 %) were concordant with the currently available literature.

Original languageEnglish
Pages (from-to)697-701
Number of pages5
JournalIrish journal of medical science
Issue number4
Publication statusPublished - Dec 2013

Keywords / Materials (for Non-textual outputs)

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Astrocytoma
  • Central Nervous System Neoplasms
  • Chemotherapy, Adjuvant
  • Child
  • Child, Preschool
  • Female
  • Glioblastoma
  • Headache
  • Humans
  • Infant
  • Ireland
  • Male
  • Medical Audit
  • Middle Aged
  • Motor Neuron Disease
  • Neoplasm Grading
  • Neurosurgical Procedures
  • Radiotherapy, Adjuvant
  • Retrospective Studies
  • Seizures
  • Tertiary Care Centers
  • Thromboembolism
  • Treatment Outcome
  • Young Adult


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