A retrospective audit of 200 cases of CNS tumours and their surgical management in a tertiary care centre

F E Muhamat Nor; J C Marks; Chandrasekaran Kaliaperumal

doi:10.1007/s11845-013-0959-1

A retrospective audit of 200 cases of CNS tumours and their surgical management in a tertiary care centre

F E Muhamat Nor, J C Marks, Chandrasekaran Kaliaperumal

Research output: Contribution to journal › Article › peer-review

Abstract

AIMS: To study the nature of the tumours managed in the Irish population.

METHODS: This audit research was completed via a retrospective medical review on 200 patients with CNS tumours managed in a tertiary care centre between 2008 and 2009.

RESULTS: The mean age was 53 years. The male:female ratio was 2:1. The majority were glioblastomas and astrocytomas. Grade IV tumours were predominant (65.5 %). Headaches (37 %), motor weakness (32 %) and seizures (25.5 %) were the highest presentations. The commonest sites affected were the left parietal and left temporal lobes. There were 17.5 % operative morbidities with motor weakness (22.9 %), seizure (14.3 %) and thrombo-embolism (14.3 %) dominating and significant association to surgical radicality (p = 0.041). 3.5 % operative mortalities were reported. 52.5 and 62.5 % of patients received adjuvant chemotherapy and radiotherapy, respectively.

CONCLUSIONS: Patients with CNS tumours typically had multiple presentations. More extensive surgical resection was associated with higher postoperative morbidities (p = 0.041). The 30-day postoperative morbidity (17.5 %) and mortality (3.5 %) were concordant with the currently available literature.

Original language	English
Pages (from-to)	697-701
Number of pages	5
Journal	Irish journal of medical science
Volume	182
Issue number	4
DOIs	https://doi.org/10.1007/s11845-013-0959-1
Publication status	Published - Dec 2013

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Astrocytoma
Central Nervous System Neoplasms
Chemotherapy, Adjuvant
Child
Child, Preschool
Female
Glioblastoma
Headache
Humans
Infant
Ireland
Male
Medical Audit
Middle Aged
Motor Neuron Disease
Neoplasm Grading
Neurosurgical Procedures
Radiotherapy, Adjuvant
Retrospective Studies
Seizures
Tertiary Care Centers
Thromboembolism
Treatment Outcome
Young Adult

Access to Document

10.1007/s11845-013-0959-1

Cite this

@article{125b9b2f51604a22a9d76d8a89618892,

title = "A retrospective audit of 200 cases of CNS tumours and their surgical management in a tertiary care centre",

abstract = "AIMS: To study the nature of the tumours managed in the Irish population.METHODS: This audit research was completed via a retrospective medical review on 200 patients with CNS tumours managed in a tertiary care centre between 2008 and 2009.RESULTS: The mean age was 53 years. The male:female ratio was 2:1. The majority were glioblastomas and astrocytomas. Grade IV tumours were predominant (65.5 %). Headaches (37 %), motor weakness (32 %) and seizures (25.5 %) were the highest presentations. The commonest sites affected were the left parietal and left temporal lobes. There were 17.5 % operative morbidities with motor weakness (22.9 %), seizure (14.3 %) and thrombo-embolism (14.3 %) dominating and significant association to surgical radicality (p = 0.041). 3.5 % operative mortalities were reported. 52.5 and 62.5 % of patients received adjuvant chemotherapy and radiotherapy, respectively.CONCLUSIONS: Patients with CNS tumours typically had multiple presentations. More extensive surgical resection was associated with higher postoperative morbidities (p = 0.041). The 30-day postoperative morbidity (17.5 %) and mortality (3.5 %) were concordant with the currently available literature.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Astrocytoma, Central Nervous System Neoplasms, Chemotherapy, Adjuvant, Child, Child, Preschool, Female, Glioblastoma, Headache, Humans, Infant, Ireland, Male, Medical Audit, Middle Aged, Motor Neuron Disease, Neoplasm Grading, Neurosurgical Procedures, Radiotherapy, Adjuvant, Retrospective Studies, Seizures, Tertiary Care Centers, Thromboembolism, Treatment Outcome, Young Adult",

author = "{Muhamat Nor}, {F E} and Marks, {J C} and Chandrasekaran Kaliaperumal",

year = "2013",

month = dec,

doi = "10.1007/s11845-013-0959-1",

language = "English",

volume = "182",

pages = "697--701",

journal = "Irish journal of medical science",

issn = "0021-1265",

publisher = "Springer London",

number = "4",

}

TY - JOUR

T1 - A retrospective audit of 200 cases of CNS tumours and their surgical management in a tertiary care centre

AU - Muhamat Nor, F E

AU - Marks, J C

AU - Kaliaperumal, Chandrasekaran

PY - 2013/12

Y1 - 2013/12

N2 - AIMS: To study the nature of the tumours managed in the Irish population.METHODS: This audit research was completed via a retrospective medical review on 200 patients with CNS tumours managed in a tertiary care centre between 2008 and 2009.RESULTS: The mean age was 53 years. The male:female ratio was 2:1. The majority were glioblastomas and astrocytomas. Grade IV tumours were predominant (65.5 %). Headaches (37 %), motor weakness (32 %) and seizures (25.5 %) were the highest presentations. The commonest sites affected were the left parietal and left temporal lobes. There were 17.5 % operative morbidities with motor weakness (22.9 %), seizure (14.3 %) and thrombo-embolism (14.3 %) dominating and significant association to surgical radicality (p = 0.041). 3.5 % operative mortalities were reported. 52.5 and 62.5 % of patients received adjuvant chemotherapy and radiotherapy, respectively.CONCLUSIONS: Patients with CNS tumours typically had multiple presentations. More extensive surgical resection was associated with higher postoperative morbidities (p = 0.041). The 30-day postoperative morbidity (17.5 %) and mortality (3.5 %) were concordant with the currently available literature.

AB - AIMS: To study the nature of the tumours managed in the Irish population.METHODS: This audit research was completed via a retrospective medical review on 200 patients with CNS tumours managed in a tertiary care centre between 2008 and 2009.RESULTS: The mean age was 53 years. The male:female ratio was 2:1. The majority were glioblastomas and astrocytomas. Grade IV tumours were predominant (65.5 %). Headaches (37 %), motor weakness (32 %) and seizures (25.5 %) were the highest presentations. The commonest sites affected were the left parietal and left temporal lobes. There were 17.5 % operative morbidities with motor weakness (22.9 %), seizure (14.3 %) and thrombo-embolism (14.3 %) dominating and significant association to surgical radicality (p = 0.041). 3.5 % operative mortalities were reported. 52.5 and 62.5 % of patients received adjuvant chemotherapy and radiotherapy, respectively.CONCLUSIONS: Patients with CNS tumours typically had multiple presentations. More extensive surgical resection was associated with higher postoperative morbidities (p = 0.041). The 30-day postoperative morbidity (17.5 %) and mortality (3.5 %) were concordant with the currently available literature.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Astrocytoma

KW - Central Nervous System Neoplasms

KW - Chemotherapy, Adjuvant

KW - Child

KW - Child, Preschool

KW - Female

KW - Glioblastoma

KW - Headache

KW - Humans

KW - Infant

KW - Ireland

KW - Male

KW - Medical Audit

KW - Middle Aged

KW - Motor Neuron Disease

KW - Neoplasm Grading

KW - Neurosurgical Procedures

KW - Radiotherapy, Adjuvant

KW - Retrospective Studies

KW - Seizures

KW - Tertiary Care Centers

KW - Thromboembolism

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1007/s11845-013-0959-1

DO - 10.1007/s11845-013-0959-1

M3 - Article

C2 - 23645548

VL - 182

SP - 697

EP - 701

JO - Irish journal of medical science

JF - Irish journal of medical science

SN - 0021-1265

IS - 4

ER -

A retrospective audit of 200 cases of CNS tumours and their surgical management in a tertiary care centre

Abstract

Keywords

Access to Document

Fingerprint

Cite this