A retrospective study on the use of acepromazine maleate in dogs with seizures

Karen M. Tobias*, Katia Marioni-Henry

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Use of acepromazine (i.e., acetylpromazine) maleate in dogs with a history of seizures is reportedly contraindicated because of the risk of decreasing the seizure threshold in these animals. In this retrospective study, acepromazine was administered for tranquilization to 36 dogs with a prior history of seizures and to decrease seizure activity in 11 dogs. No seizures were seen within 16 hours of acepromazine administration in the 36 dogs that received the drug for tranquilization during hospitalization. After acepromazine administration, seizures abated for 1.5 to 8 hours (n=6) or did not recur (n=2) in eight of 10 dogs that were actively seizing. Excitement-induced seizure frequency was reduced for 2 months in one dog.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalJournal of the american animal hospital association
Volume42
Issue number4
Publication statusPublished - 2006

Keywords / Materials (for Non-textual outputs)

  • EPILEPSY
  • DRUGS

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