A review of the natural history, toxinology, diagnosis and clinical management of Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) poisoning

Veronika Bandara, Scott A. Weinstein, Julian White, Michael Eddleston

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) are potentially lethal plants after ingestion. Poisoning by these plants is a common toxicological emergency in tropical and subtropical parts of the world and intentional self-harm using T. peruviana is prevalent in South Asian countries, especially India and Sri Lanka. All parts of these plants are toxic, and contain a variety of cardiac glycosides including neriifolin, thevetin A, thevetin B, and oleandrin. Ingestion of either oleander results in nausea, vomiting, abdominal pain, diarrhoea, dysrhythmias, and hyperkalemia. In most cases, clinical management of poisoning by either N. oleander or T peruviana involves administration of activated charcoal and supportive care. Digoxin specific Fab fragments are an effective treatment of acute intoxication by either species. However, where limited economic resources restrict the use of such Fab fragments, treatment of severely poisoned patients is difficult. Data from case reports and clinical studies were reviewed to identify treatments supported by evidence for the management of poisoning by N. oleander and T peruviana. (C) 2010 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)273-281
Number of pages9
JournalToxicon: An Interdisciplinary Journal on the Toxins Derived from Animals, Plants and Microorganisms
Volume56
Issue number3
DOIs
Publication statusPublished - 1 Sep 2010

Fingerprint

Dive into the research topics of 'A review of the natural history, toxinology, diagnosis and clinical management of Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) poisoning'. Together they form a unique fingerprint.

Cite this