A roadmap for the human gut cell atlas

Matthias Zilbauer; Kylie James; Mandeep Kaur; Sebastian Pott; Zhixing Li; Albert Burger; Jay Thiagarajah; Joseph Burclaff; Frode L Jahnsen; Francesca Perrone; Alexander Ross; Gianluca Matteoli; Nathalie Stakenborg; Tomohisa Sujino; Andreas Moor; Raquel Bartolome-Casado; Espen S. Baekkevold; Ran Zhou; Bingqing Xie; Ken Lau; Shahida Din; Scott  Magnes; Qiuming Yao; Semir Beyaz; Mark J Arends; Alexandre Denadai-Souza; Lori Coburn; Jellert Gaublomme; Richard Baldock; Irene Papatheodorou; Jose Ordovas-Montanes; Guy E Boeckxstaens; Anna Hupalowska; Sarah A Teichmann; Aviv Regev; Ramnik Xavier; Alison Simmons; Michael P. Snyder; Keith Wilson

doi:10.1038/s41575-023-00784-1

A roadmap for the human gut cell atlas

Matthias Zilbauer, Kylie James, Mandeep Kaur, Sebastian Pott, Zhixing Li, Albert Burger, Jay Thiagarajah, Joseph Burclaff, Frode L Jahnsen, Francesca Perrone, Alexander Ross, Gianluca Matteoli, Nathalie Stakenborg, Tomohisa Sujino, Andreas Moor, Raquel Bartolome-Casado, Espen S. Baekkevold, Ran Zhou, Bingqing Xie, Ken LauShahida Din, Scott Magnes, Qiuming Yao, Semir Beyaz, Mark J Arends, Alexandre Denadai-Souza, Lori Coburn, Jellert Gaublomme, Richard Baldock, Irene Papatheodorou, Jose Ordovas-Montanes, Guy E Boeckxstaens, Anna Hupalowska, Sarah A Teichmann, Aviv Regev, Ramnik Xavier, Alison Simmons, Michael P. Snyder, Keith Wilson

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Nature Reviews Gastroenterology & Hepatology
Early online date	31 May 2023
DOIs	https://doi.org/10.1038/s41575-023-00784-1
Publication status	E-pub ahead of print - 31 May 2023

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10.1038/s41575-023-00784-1

A Roadmap for the Human Gut Cell AtlasAccepted author manuscript, 301 KB

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Zilbauer, M., James, K., Kaur, M., Pott, S., Li, Z., Burger, A., Thiagarajah, J., Burclaff, J., Jahnsen, F. L., Perrone, F., Ross, A., Matteoli, G., Stakenborg, N., Sujino, T., Moor, A., Bartolome-Casado, R., Baekkevold, E. S., Zhou, R., Xie, B., ... Wilson, K. (2023). A roadmap for the human gut cell atlas. Nature Reviews Gastroenterology & Hepatology. Advance online publication. https://doi.org/10.1038/s41575-023-00784-1

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title = "A roadmap for the human gut cell atlas",

author = "Matthias Zilbauer and Kylie James and Mandeep Kaur and Sebastian Pott and Zhixing Li and Albert Burger and Jay Thiagarajah and Joseph Burclaff and Jahnsen, {Frode L} and Francesca Perrone and Alexander Ross and Gianluca Matteoli and Nathalie Stakenborg and Tomohisa Sujino and Andreas Moor and Raquel Bartolome-Casado and Baekkevold, {Espen S.} and Ran Zhou and Bingqing Xie and Ken Lau and Shahida Din and Scott Magnes and Qiuming Yao and Semir Beyaz and Arends, {Mark J} and Alexandre Denadai-Souza and Lori Coburn and Jellert Gaublomme and Richard Baldock and Irene Papatheodorou and Jose Ordovas-Montanes and Boeckxstaens, {Guy E} and Anna Hupalowska and Teichmann, {Sarah A} and Aviv Regev and Ramnik Xavier and Alison Simmons and Snyder, {Michael P.} and Keith Wilson",

note = "Funding Information: In the past 3 years, S.A.T. has consulted or been a member of scientific advisory boards at Roche, Genentech, Biogen, GlaxoSmithKline, Qiagen and ForeSite Labs and is an equity holder of Transition Bio. G.M. has received grant funding from Boehringer Ingelheim. A. Regev is a co-founder and equity holder of Celsius Therapeutics, an equity holder in Immunitas, and was a SAB member of ThermoFisher Scientific, Syros Pharmaceuticals, Neogene Therapeutics and Asimov until 31 July 2020. Since 1 August 2020, A. Regev has been an employee of Genentech and has equity in Roche. A. Regev is an inventor on patents and patent applications filed at the Broad Institute related to single-cell genomics. The remaining authors declare no competing interests. Funding Information: This publication is part of the Human Cell Atlas (HCA) www.humancellatlas.org/publications . The HCA initiative receives funding from The Wellcome Trust, the UK Research and Innovation Medical Research Council, EU Horizon 2020, INSERM (HuDeCA), and the Knut and Alice Wallenberg and Erling-Persson foundations. We thank the HCA Executive Office for their support. The Gut Cell Atlas is organized by The Leona M. and Harry B. Helmsley Charitable Trust and provides funding for members in the form of project grants. M.Z. was supported by an MRC New Investigator research grant (MR/T001917/1) and a project grant from the Great Ormond Street Hospital Children{\textquoteright}s Charity, Sparks (V4519); K.S.L. was supported by NIDDK R01DK103831, and The Helmsley Trust — G-1903-03793. S.T.M. received funding from National Institutes of Health USA R01DK115806 and P30DK034987. T.S. was supported by the Japanese Science and Technology (JST) FOREST and the Japanese Society for the Promotion of Science (JSPS) (21K18272). L.A.C. and K.T.W. were supported by The Helmsley Charitable Trust — G-1903-03793. K.T.W. was also supported by NIDDK R01DK128200. L.A.C. was supported by a Veterans Affairs Merit Award 1I01BX004366. M.K. was supported by the National Research Foundation, South Africa grant no: 129356. Publisher Copyright: {\textcopyright} 2023, Springer Nature Limited.",

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doi = "10.1038/s41575-023-00784-1",

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Zilbauer, M, James, K, Kaur, M, Pott, S, Li, Z, Burger, A, Thiagarajah, J, Burclaff, J, Jahnsen, FL, Perrone, F, Ross, A, Matteoli, G, Stakenborg, N, Sujino, T, Moor, A, Bartolome-Casado, R, Baekkevold, ES, Zhou, R, Xie, B, Lau, K, Din, S, Magnes, S, Yao, Q, Beyaz, S, Arends, MJ, Denadai-Souza, A, Coburn, L, Gaublomme, J, Baldock, R, Papatheodorou, I, Ordovas-Montanes, J, Boeckxstaens, GE, Hupalowska, A, Teichmann, SA, Regev, A, Xavier, R, Simmons, A, Snyder, MP & Wilson, K 2023, 'A roadmap for the human gut cell atlas', Nature Reviews Gastroenterology & Hepatology. https://doi.org/10.1038/s41575-023-00784-1

TY - JOUR

T1 - A roadmap for the human gut cell atlas

AU - Zilbauer, Matthias

AU - James, Kylie

AU - Kaur, Mandeep

AU - Pott, Sebastian

AU - Li, Zhixing

AU - Burger, Albert

AU - Thiagarajah, Jay

AU - Burclaff, Joseph

AU - Jahnsen, Frode L

AU - Perrone, Francesca

AU - Ross, Alexander

AU - Matteoli, Gianluca

AU - Stakenborg, Nathalie

AU - Sujino, Tomohisa

AU - Moor, Andreas

AU - Bartolome-Casado, Raquel

AU - Baekkevold, Espen S.

AU - Zhou, Ran

AU - Xie, Bingqing

AU - Lau, Ken

AU - Din, Shahida

AU - Magnes, Scott

AU - Yao, Qiuming

AU - Beyaz, Semir

AU - Arends, Mark J

AU - Denadai-Souza, Alexandre

AU - Coburn, Lori

AU - Gaublomme, Jellert

AU - Baldock, Richard

AU - Papatheodorou, Irene

AU - Ordovas-Montanes, Jose

AU - Boeckxstaens, Guy E

AU - Hupalowska, Anna

AU - Teichmann, Sarah A

AU - Regev, Aviv

AU - Xavier, Ramnik

AU - Simmons, Alison

AU - Snyder, Michael P.

AU - Wilson, Keith

N1 - Funding Information: In the past 3 years, S.A.T. has consulted or been a member of scientific advisory boards at Roche, Genentech, Biogen, GlaxoSmithKline, Qiagen and ForeSite Labs and is an equity holder of Transition Bio. G.M. has received grant funding from Boehringer Ingelheim. A. Regev is a co-founder and equity holder of Celsius Therapeutics, an equity holder in Immunitas, and was a SAB member of ThermoFisher Scientific, Syros Pharmaceuticals, Neogene Therapeutics and Asimov until 31 July 2020. Since 1 August 2020, A. Regev has been an employee of Genentech and has equity in Roche. A. Regev is an inventor on patents and patent applications filed at the Broad Institute related to single-cell genomics. The remaining authors declare no competing interests. Funding Information: This publication is part of the Human Cell Atlas (HCA) www.humancellatlas.org/publications . The HCA initiative receives funding from The Wellcome Trust, the UK Research and Innovation Medical Research Council, EU Horizon 2020, INSERM (HuDeCA), and the Knut and Alice Wallenberg and Erling-Persson foundations. We thank the HCA Executive Office for their support. The Gut Cell Atlas is organized by The Leona M. and Harry B. Helmsley Charitable Trust and provides funding for members in the form of project grants. M.Z. was supported by an MRC New Investigator research grant (MR/T001917/1) and a project grant from the Great Ormond Street Hospital Children’s Charity, Sparks (V4519); K.S.L. was supported by NIDDK R01DK103831, and The Helmsley Trust — G-1903-03793. S.T.M. received funding from National Institutes of Health USA R01DK115806 and P30DK034987. T.S. was supported by the Japanese Science and Technology (JST) FOREST and the Japanese Society for the Promotion of Science (JSPS) (21K18272). L.A.C. and K.T.W. were supported by The Helmsley Charitable Trust — G-1903-03793. K.T.W. was also supported by NIDDK R01DK128200. L.A.C. was supported by a Veterans Affairs Merit Award 1I01BX004366. M.K. was supported by the National Research Foundation, South Africa grant no: 129356. Publisher Copyright: © 2023, Springer Nature Limited.

PY - 2023/5/31

Y1 - 2023/5/31

U2 - 10.1038/s41575-023-00784-1

DO - 10.1038/s41575-023-00784-1

M3 - Article

SN - 1759-5045

JO - Nature Reviews Gastroenterology & Hepatology

JF - Nature Reviews Gastroenterology & Hepatology

ER -