Projects per year
Abstract / Description of output
decidualization response (weight/proportion), transcriptomic changes, and
morphological and functional parameters of vascular development. These
investigations revealed a striking effect of 5a-reductase deficiency on the
decidualization response. Furthermore, vessel permeability and
transcriptional regulation of angiogenesis signaling pathways, particularly
those that involved vascular endothelial growth factor (VEGF), were disrupted
in the absence of 5a-reductase. In Srd5a1-/- mice, injection of dihydrotestosterone co-incident with decidualization restored
decidualization responses, vessel permeability, and expression of angiogenesis genes to wild type levels. Androgen availability declines with age which may contribute to age-related risk of pregnancy disorders. These findings show that intracrine androgen signaling is required for optimal decidualization in vivo and confirm a major role for androgens in the development of the vasculature during decidualization through regulation of the VEGF pathway. These findings highlight new opportunities for improving age-related deficits in fertility and pregnancy health by targeting androgendependent signaling in the endometrium.
FingerprintDive into the research topics of 'A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization'. Together they form a unique fingerprint.
1/01/21 → 31/12/25
1/10/11 → 31/03/17
Alison Munro (Manager) & Kenneth Macleod (Other)Deanery of Molecular, Genetic and Population Health Sciences