A scalable mediator approach to process large biomedical 3-D images

Konstantinos Liakos, Albert Burger, Richard Baldock

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The Edinburgh Mouse Atlas is a spatial-temporal framework to store and analyze biological data including three-dimensional (3-D) images that relate to mouse embryo development. The purpose of the system is the analysis and querying of complex spatial patterns, in particular the patterns of gene activity during embryo development. The framework holds large 3-D gray level images and is implemented in part as an object-oriented database. In this paper, we propose a dynamic layered architecture, based on the mediator approach, for the design of a transparent and scalable distributed system which can process objects that can exceed 1 GB in size. The system's data are distributed and/or declustered across a number of image servers and are processed by specialized mediators.
Original languageEnglish
Pages (from-to)354-9
Number of pages6
JournalIEEE Transactions on Information Technology in Biomedicine
Issue number3
Publication statusPublished - Sept 2004

Keywords / Materials (for Non-textual outputs)

  • Software
  • Imaging, Three-Dimensional
  • Animals
  • Image Interpretation, Computer-Assisted
  • Biomedical Research
  • Artificial Intelligence
  • Databases, Factual
  • Brain
  • Algorithms
  • Mice
  • User-Computer Interface
  • Database Management Systems


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