A scaleable and defined system for generating neural stem cells from human embryonic stem cells

Alexis J. Joannides, Christelle Fiore-Heriche, Alysia A. Battersby, Pandula Athauda-Arachchi, Isabelle A. Bouhon, Lydia Williams, Kristine Westmore, Paul J. Kemp, Alastair Compston, Nicholas D. Allen, Siddharthan Chandran*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled manner is fundamental to developing cell-based therapies and studying human developmental mechanisms. We report a novel, scaleable, and widely applicable system for deriving and propagating neural stem cells from hESCs without the use of animal products, proprietary formulations, or genetic manipulation. This system provides a definitive platform for studying human neural development and has potential therapeutic implications.

Original languageEnglish
Pages (from-to)731-737
Number of pages7
JournalSTEM CELLS
Volume25
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • human embryonic stem cells
  • neural stem cells
  • defined conditions
  • fibroblast growth factor
  • HUMAN ES CELLS
  • DIRECTED DIFFERENTIATION
  • PARKINSONS-DISEASE
  • SELF-RENEWAL
  • IN-VITRO
  • DOPAMINERGIC-NEURONS
  • PROGENITOR CELLS
  • PRECURSOR CELLS
  • CULTURE
  • DERIVATION

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