A search for quantitative trait loci for milk production traits on chromosome 6 in Finnish Ayrshire cattle

R J Velmala, H J Vilkki, K T Elo, D J de Koning, A V Mäki-Tanila

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Cattle chromosome 6 was scanned with 11 markers, ten microsatellites and the casein haplotype, to identify quantitative trait loci (QTLs) affecting the following milk production traits: milk yield, fat percentage, fat yield, protein percentage and protein yield. Twelve Finnish Ayrshire half-sib families with a total of 480 sons were genotyped and used in a grand-daughter design. Interval mapping was performed with a multiple-marker regression approach with a one-QTL and a two-QTL model, and the significance threshold values were determined empirically using a permutation test. Across-family analysis with the one-QTL model revealed an effect on protein percentage (P <0.05) and on milk yield (P <0.05). The analysis with the two-QTL model identified significant effects (P <0.05) on protein percentage, milk yield, and fat yield. Comparing these two cases, the results suggest the existence of two QTLs on chromosome 6 with an effect on milk production traits. One of the QTLs was located around the casein genes. As the other QTL was similar in location and effect to a QTL found previously in Holstein-Friesians, an identity-by-descent approach could be applied to fine map this region.
Original languageEnglish
Pages (from-to)136-43
Number of pages8
JournalAnimal Genetics
Volume30
Issue number2
Publication statusPublished - Apr 1999

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Caseins
  • Cattle
  • Chromosome Mapping
  • Computer Simulation
  • DNA Primers
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Finland
  • Inbreeding
  • Lactation
  • Lipids
  • Male
  • Microsatellite Repeats
  • Milk
  • Milk Proteins
  • Models, Genetic
  • Polymerase Chain Reaction
  • Quantitative Trait, Heritable
  • Regression Analysis
  • Semen

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