A short biomimetic synthesis of the meroterpenoids guajadial and psidial A

A.L. Lawrence, R.M. Adlington, J.E. Baldwin, V. Lee, J.A. Kershaw, A.L. Thompson, Andrew Lawrence

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The biosynthesis of the meroterpenoid guajadial was previously hypothesized to occur via a hetero-Diels-Alder reaction between caryophyllene and an o-quinone methide. This hypothesis has been verified via the biomimetic synthesis of guajadial and psidial A in an aqueous three-component coupling reaction, between caryophyllene, benzaldehyde, and diformylphloroglucinol.
Original languageEnglish
Pages (from-to)1676-1679
Number of pages4
JournalOrganic letters
Volume12
Issue number8
DOIs
Publication statusPublished - 16 Apr 2010

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