A simple genetic architecture underlies morphological variation in dogs

Adam R Boyko; Pascale Quignon; Lin Li; Jeffrey J Schoenebeck; Jeremiah D Degenhardt; Kirk E Lohmueller; Keyan Zhao; Abra Brisbin; Heidi G Parker; Bridgett M vonHoldt; Michele Cargill; Adam Auton; Andy Reynolds; Abdel G Elkahloun; Marta Castelhano; Dana S Mosher; Nathan B Sutter; Gary S Johnson; John Novembre; Melissa J Hubisz; Adam Siepel; Robert K Wayne; Carlos D Bustamante; Elaine A Ostrander

doi:10.1371/journal.pbio.1000451

A simple genetic architecture underlies morphological variation in dogs

Adam R Boyko, Pascale Quignon, Lin Li, Jeffrey J Schoenebeck, Jeremiah D Degenhardt, Kirk E Lohmueller, Keyan Zhao, Abra Brisbin, Heidi G Parker, Bridgett M vonHoldt, Michele Cargill, Adam Auton, Andy Reynolds, Abdel G Elkahloun, Marta Castelhano, Dana S Mosher, Nathan B Sutter, Gary S Johnson, John Novembre, Melissa J HubiszAdam Siepel, Robert K Wayne, Carlos D Bustamante, Elaine A Ostrander

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 single-nucleotide polymorphisms (SNPs). Coupling this genomic resource with external measurements from breed standards and individuals as well as skeletal measurements from museum specimens, we identify 51 regions of the dog genome associated with phenotypic variation among breeds in 57 traits. The complex traits include average breed body size and external body dimensions and cranial, dental, and long bone shape and size with and without allometric scaling. In contrast to the results from association mapping of quantitative traits in humans and domesticated plants, we find that across dog breeds, a small number of quantitative trait loci (

Original language	English
Pages (from-to)	e1000451
Journal	PLoS Biology
Volume	8
Issue number	8
DOIs	https://doi.org/10.1371/journal.pbio.1000451
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

Animals
Animals, Domestic
Body Size
Dogs
Genetic Variation
Genome
Genome-Wide Association Study
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait Loci

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10.1371/journal.pbio.1000451

A simple genetic architecture underlies morphological variation in dogs
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http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1000451

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Boyko, A. R., Quignon, P., Li, L., Schoenebeck, J. J., Degenhardt, J. D., Lohmueller, K. E., Zhao, K., Brisbin, A., Parker, H. G., vonHoldt, B. M., Cargill, M., Auton, A., Reynolds, A., Elkahloun, A. G., Castelhano, M., Mosher, D. S., Sutter, N. B., Johnson, G. S., Novembre, J., ... Ostrander, E. A. (2010). A simple genetic architecture underlies morphological variation in dogs. PLoS Biology, 8(8), e1000451. https://doi.org/10.1371/journal.pbio.1000451

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abstract = "Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 single-nucleotide polymorphisms (SNPs). Coupling this genomic resource with external measurements from breed standards and individuals as well as skeletal measurements from museum specimens, we identify 51 regions of the dog genome associated with phenotypic variation among breeds in 57 traits. The complex traits include average breed body size and external body dimensions and cranial, dental, and long bone shape and size with and without allometric scaling. In contrast to the results from association mapping of quantitative traits in humans and domesticated plants, we find that across dog breeds, a small number of quantitative trait loci (",

keywords = "Animals, Animals, Domestic, Body Size, Dogs, Genetic Variation, Genome, Genome-Wide Association Study, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci",

author = "Boyko, {Adam R} and Pascale Quignon and Lin Li and Schoenebeck, {Jeffrey J} and Degenhardt, {Jeremiah D} and Lohmueller, {Kirk E} and Keyan Zhao and Abra Brisbin and Parker, {Heidi G} and vonHoldt, {Bridgett M} and Michele Cargill and Adam Auton and Andy Reynolds and Elkahloun, {Abdel G} and Marta Castelhano and Mosher, {Dana S} and Sutter, {Nathan B} and Johnson, {Gary S} and John Novembre and Hubisz, {Melissa J} and Adam Siepel and Wayne, {Robert K} and Bustamante, {Carlos D} and Ostrander, {Elaine A}",

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Boyko, AR, Quignon, P, Li, L, Schoenebeck, JJ, Degenhardt, JD, Lohmueller, KE, Zhao, K, Brisbin, A, Parker, HG, vonHoldt, BM, Cargill, M, Auton, A, Reynolds, A, Elkahloun, AG, Castelhano, M, Mosher, DS, Sutter, NB, Johnson, GS, Novembre, J, Hubisz, MJ, Siepel, A, Wayne, RK, Bustamante, CD & Ostrander, EA 2010, 'A simple genetic architecture underlies morphological variation in dogs', PLoS Biology, vol. 8, no. 8, pp. e1000451. https://doi.org/10.1371/journal.pbio.1000451

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AU - Quignon, Pascale

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AU - Lohmueller, Kirk E

AU - Zhao, Keyan

AU - Brisbin, Abra

AU - Parker, Heidi G

AU - vonHoldt, Bridgett M

AU - Cargill, Michele

AU - Auton, Adam

AU - Reynolds, Andy

AU - Elkahloun, Abdel G

AU - Castelhano, Marta

AU - Mosher, Dana S

AU - Sutter, Nathan B

AU - Johnson, Gary S

AU - Novembre, John

AU - Hubisz, Melissa J

AU - Siepel, Adam

AU - Wayne, Robert K

AU - Bustamante, Carlos D

AU - Ostrander, Elaine A

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AB - Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 single-nucleotide polymorphisms (SNPs). Coupling this genomic resource with external measurements from breed standards and individuals as well as skeletal measurements from museum specimens, we identify 51 regions of the dog genome associated with phenotypic variation among breeds in 57 traits. The complex traits include average breed body size and external body dimensions and cranial, dental, and long bone shape and size with and without allometric scaling. In contrast to the results from association mapping of quantitative traits in humans and domesticated plants, we find that across dog breeds, a small number of quantitative trait loci (

KW - Animals

KW - Animals, Domestic

KW - Body Size

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KW - Genetic Variation

KW - Genome

KW - Genome-Wide Association Study

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KW - Quantitative Trait Loci

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SP - e1000451

JO - PLoS Biology

JF - PLoS Biology

IS - 8

ER -

A simple genetic architecture underlies morphological variation in dogs

Abstract

Keywords / Materials (for Non-textual outputs)

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