A simple genetic architecture underlies morphological variation in dogs

Adam R Boyko, Pascale Quignon, Lin Li, Jeffrey J Schoenebeck, Jeremiah D Degenhardt, Kirk E Lohmueller, Keyan Zhao, Abra Brisbin, Heidi G Parker, Bridgett M vonHoldt, Michele Cargill, Adam Auton, Andy Reynolds, Abdel G Elkahloun, Marta Castelhano, Dana S Mosher, Nathan B Sutter, Gary S Johnson, John Novembre, Melissa J HubiszAdam Siepel, Robert K Wayne, Carlos D Bustamante, Elaine A Ostrander

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 single-nucleotide polymorphisms (SNPs). Coupling this genomic resource with external measurements from breed standards and individuals as well as skeletal measurements from museum specimens, we identify 51 regions of the dog genome associated with phenotypic variation among breeds in 57 traits. The complex traits include average breed body size and external body dimensions and cranial, dental, and long bone shape and size with and without allometric scaling. In contrast to the results from association mapping of quantitative traits in humans and domesticated plants, we find that across dog breeds, a small number of quantitative trait loci (
Original languageEnglish
Pages (from-to)e1000451
JournalPLoS Biology
Issue number8
Publication statusPublished - 2010

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Animals, Domestic
  • Body Size
  • Dogs
  • Genetic Variation
  • Genome
  • Genome-Wide Association Study
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci


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