New SIMS U-Pb (zircon) data for intrusive rocks of the Macquarie Arc and adjacent granitic batholiths of the Lachlan Orogen (southeastern Australia) provide insight into the magmatic and tectonic evolution of the paleo-Pacific Gondwana margin in the early Paleozoic. These data are augmented by Re-Os dates on molybdenite from four Cu-Au mineralised porphyry systems to place minimum age constraints on igneous crystallization. The simplicity of the zircon age distributions, and absence of older inheritance, stands in contrast to previous geochronological studies. The earliest magmatism within the Macquarie Arc is registered by a ca. 503 Ma gabbro from the Monza igneous complex, whereas a monzodiorite from the same drillhole records the youngest (ca. 432 Ma). Igneous activity in the Macquarie Arc thus overlapped deformation and magmatism in the craton-proximal Delamerian Orogen to the west, and the emplacement of the Lachlan granitic batholiths at 435–430 Ma; the thermal pulse associated with the latter may have triggered the formation of richly mineralised Silurian porphyries in the Macquarie Arc. The juvenile Hf isotope signature of the Monza Gabbro, together with the lack of zircon inheritance and the radiogenic Hf-Nd isotope systematics of Ordovician Macquarie Arc rocks, is consistent with early development of the arc, or a precursor magmatic belt, in an oceanic setting remote from continental influences, and with the arc being built on primitive Cambrian mafic crust. Outboard arc magmatism in the Cambrian may have initiated in response to convergent Delamerian orogenesis adjacent the Gondwana margin. Overlapping radiogenic isotope-time trends are consistent with the evolution of the Macquarie Arc and the Gondwana continental margin being linked from the Cambrian to the Silurian. These data provide further evidence for the growth of continental crust along the southeastern Australian segment of this margin being related to the dynamics of an extensional accretionary orogenic system.