A simulation model to investigate interactions between first season grazing calves and Ostertagia ostertagi

Zoe Berk, Stephen C. Bishop, Andrew B. Forbes, Ilias Kyriazakis

Research output: Contribution to journalArticlepeer-review

Abstract

A dynamic, deterministic model was developed to investigate the consequences of parasitism with Ostertagia ostertagi, the most prevalent and economically important gastrointestinal parasite of cattle in temperate regions. Interactions between host and parasite were considered to predict the level of parasitism and performance of an infected calf. Key model inputs included calf intrinsic growth rate, feed quality and mode and level of infection. The effects of these varied inputs were simulated on a daily basis for key parasitological (worm burden, total egg output and faecal egg count) and performance outputs (feed intake and bodyweight) over a 6 month grazing period. Data from published literature were used to parameterise the model and its sensitivity was tested for uncertain parameters by a Latin hypercube sensitivity design. For the latter each parameter tested was subject to a 20% coefficient of variation. The model parasitological outputs were most sensitive to the immune rate parameters that affected overall worm burdens. The model predicted the expected larger worm burdens along with disproportionately greater body weight losses with increasing daily infection levels. The model was validated against published literature using graphical and statistical comparisons. Its predictions were quantitatively consistent with the parasitological outputs of published experiments in which calves were subjected to different infection levels. The consequences of model weaknesses are discussed and point towards model improvements. Future work should focus on developing a stochastic model to account for calf variation in performance and immune response; this will ultimately be used to test the effectiveness of different parasite control strategies in naturally infected calf populations.
Original languageEnglish
Pages (from-to)198-209
JournalVeterinary Parasitology
Volume226
Early online date7 May 2016
DOIs
Publication statusPublished - 15 Aug 2016

Keywords

  • calves
  • gastrointestinal parasites
  • immunity
  • modelling
  • Ostertagia ostertagi
  • parasite-induced anorexia

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