A Staphylococcus xylosus isolate with a new mecC allotype

Ewan M Harrison; Gavin K Paterson; Matthew T G Holden; Fiona J E Morgan; Anders Rhod Larsen; Andreas Petersen; Sabine Leroy; Sarne De Vliegher; Vincent Perreten; Lawrence K Fox; Theo J G M Lam; Otlis C Sampimon; Ruth N Zadoks; Sharon J Peacock; Julian Parkhill; Mark A Holmes

doi:10.1128/AAC.01882-12

A Staphylococcus xylosus isolate with a new mecC allotype

Ewan M Harrison, Gavin K Paterson, Matthew T G Holden, Fiona J E Morgan, Anders Rhod Larsen, Andreas Petersen, Sabine Leroy, Sarne De Vliegher, Vincent Perreten, Lawrence K Fox, Theo J G M Lam, Otlis C Sampimon, Ruth N Zadoks, Sharon J Peacock, Julian Parkhill, Mark A Holmes

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.

Original language	English
Pages (from-to)	1524-8
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01882-12
Publication status	Published - Mar 2013

Keywords / Materials (for Non-textual outputs)

Animals
Anti-Bacterial Agents
Bacterial Proteins
Bacterial Typing Techniques
Cattle
Genetic Loci
Genome, Bacterial
Humans
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Protein Isoforms
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Staphylococcus
Transcription Factors

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10.1128/AAC.01882-12

A Staphylococcus xylosus isolate with a new mecC allotype
Copyright © 2013, American Society for Microbiology. All Rights Reserved.
Final published version, 0.98 MB

http://aac.asm.org/content/57/3/1524

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Harrison, E. M., Paterson, G. K., Holden, M. T. G., Morgan, F. J. E., Larsen, A. R., Petersen, A., Leroy, S., De Vliegher, S., Perreten, V., Fox, L. K., Lam, T. J. G. M., Sampimon, O. C., Zadoks, R. N., Peacock, S. J., Parkhill, J., & Holmes, M. A. (2013). A Staphylococcus xylosus isolate with a new mecC allotype. Antimicrobial Agents and Chemotherapy, 57(3), 1524-8. https://doi.org/10.1128/AAC.01882-12

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title = "A Staphylococcus xylosus isolate with a new mecC allotype",

abstract = "Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.",

keywords = "Animals, Anti-Bacterial Agents, Bacterial Proteins, Bacterial Typing Techniques, Cattle, Genetic Loci, Genome, Bacterial, Humans, Methicillin Resistance, Methicillin-Resistant Staphylococcus aureus, Protein Isoforms, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Staphylococcus, Transcription Factors",

author = "Harrison, {Ewan M} and Paterson, {Gavin K} and Holden, {Matthew T G} and Morgan, {Fiona J E} and Larsen, {Anders Rhod} and Andreas Petersen and Sabine Leroy and {De Vliegher}, Sarne and Vincent Perreten and Fox, {Lawrence K} and Lam, {Theo J G M} and Sampimon, {Otlis C} and Zadoks, {Ruth N} and Peacock, {Sharon J} and Julian Parkhill and Holmes, {Mark A}",

year = "2013",

month = mar,

doi = "10.1128/AAC.01882-12",

language = "English",

volume = "57",

pages = "1524--8",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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Harrison, EM, Paterson, GK, Holden, MTG, Morgan, FJE, Larsen, AR, Petersen, A, Leroy, S, De Vliegher, S, Perreten, V, Fox, LK, Lam, TJGM, Sampimon, OC, Zadoks, RN, Peacock, SJ, Parkhill, J & Holmes, MA 2013, 'A Staphylococcus xylosus isolate with a new mecC allotype', Antimicrobial Agents and Chemotherapy, vol. 57, no. 3, pp. 1524-8. https://doi.org/10.1128/AAC.01882-12

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T1 - A Staphylococcus xylosus isolate with a new mecC allotype

AU - Harrison, Ewan M

AU - Paterson, Gavin K

AU - Holden, Matthew T G

AU - Morgan, Fiona J E

AU - Larsen, Anders Rhod

AU - Petersen, Andreas

AU - Leroy, Sabine

AU - De Vliegher, Sarne

AU - Perreten, Vincent

AU - Fox, Lawrence K

AU - Lam, Theo J G M

AU - Sampimon, Otlis C

AU - Zadoks, Ruth N

AU - Peacock, Sharon J

AU - Parkhill, Julian

AU - Holmes, Mark A

PY - 2013/3

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N2 - Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.

AB - Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.

KW - Animals

KW - Anti-Bacterial Agents

KW - Bacterial Proteins

KW - Bacterial Typing Techniques

KW - Cattle

KW - Genetic Loci

KW - Genome, Bacterial

KW - Humans

KW - Methicillin Resistance

KW - Methicillin-Resistant Staphylococcus aureus

KW - Protein Isoforms

KW - Sequence Analysis, DNA

KW - Sequence Homology, Amino Acid

KW - Staphylococcus

KW - Transcription Factors

U2 - 10.1128/AAC.01882-12

DO - 10.1128/AAC.01882-12

M3 - Article

C2 - 23274660

SN - 0066-4804

VL - 57

SP - 1524

EP - 1528

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

ER -

A Staphylococcus xylosus isolate with a new mecC allotype

Abstract

Keywords / Materials (for Non-textual outputs)

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