A Staphylococcus xylosus isolate with a new mecC allotype

Ewan M Harrison, Gavin K Paterson, Matthew T G Holden, Fiona J E Morgan, Anders Rhod Larsen, Andreas Petersen, Sabine Leroy, Sarne De Vliegher, Vincent Perreten, Lawrence K Fox, Theo J G M Lam, Otlis C Sampimon, Ruth N Zadoks, Sharon J Peacock, Julian Parkhill, Mark A Holmes

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.
Original languageEnglish
Pages (from-to)1524-8
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Issue number3
Publication statusPublished - Mar 2013

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Bacterial Typing Techniques
  • Cattle
  • Genetic Loci
  • Genome, Bacterial
  • Humans
  • Methicillin Resistance
  • Methicillin-Resistant Staphylococcus aureus
  • Protein Isoforms
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Staphylococcus
  • Transcription Factors


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