A study on lymphocyte activation in maedi-visna virus induced pneumonia

I Begara, L Lujan, J Hopkins, D D Collie, H R Miller, N J Watt

Research output: Contribution to journalArticlepeer-review

Abstract

The stage of activation of bronchoalveolar lavage fluid (BALF) lymphocytes and peripheral blood lymphocytes (PBL) from maedi-visna virus (MVV) infected (n = 7) and control (n = 7) sheep was investigated by assessing four parameters of lymphocyte activation; lymphocyte size and complexity, loss of CD5+ T cells, expression of cell surface interleukin-2 receptor (IL-2R) and expression of DR and DQ MHC Class II molecules. BALF lymphocytes from MVV-infected animals had a significant loss of CD5+ lymphocytes (P <0.05) and upregulation of DR and DQ MHC Class II molecules compared with controls, consistent with BALF lymphocyte activation. No changes in cell size and complexity or expression of IL-2R were observed. No evidence of PBL activation was detected. These findings suggest an impaired BALF lymphocyte activation during MVV infection.
Original languageEnglish
Pages (from-to)197-210
Number of pages14
JournalVeterinary Immunology and Immunopathology
Volume45
Issue number3-4
DOIs
Publication statusPublished - Apr 1995

Keywords

  • Animals
  • Sheep
  • Visna-maedi virus
  • Receptors, Interleukin-2
  • Antibodies, Monoclonal
  • Lymphocyte Activation
  • Lymphocyte Count
  • HLA-DQ Antigens
  • Pneumonia, Progressive Interstitial, of Sheep
  • HLA-DR Antigens
  • Antigens, CD
  • Antigens, CD5
  • Bronchoalveolar Lavage Fluid
  • Flow Cytometry
  • Up-Regulation
  • Immunophenotyping
  • Female
  • T-Lymphocytes

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