A sub-30 mpH resolution thin film transistor-based nanoribbon biosensing platform

Ioannis Zeimpekis, Konstantinos I. Papadimitriou*, Kai Sun, Chunxiao Hu, Peter Ashburn, Hywel Morgan, Themistoklis Prodromakis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We present a complete biosensing system that comprises a Thin Film Transistor (TFT)-based nanoribbon biosensor and a low noise, high-performance bioinstrumentation platform, capable of detecting sub-30 mpH unit changes, validated by an enzymatic biochemical reaction. The nanoribbon biosensor was fabricated top-down with an ultra-thin (15 nm) polysilicon semiconducting channel that offers excellent sensitivity to surface potential changes. The sensor is coupled to an integrated circuit (IC), which combines dual switched-capacitor integrators with high precision analog-to-digital converters (ADCs). Throughout this work, we employed both conventional pH buffer measurements as well as urea-urease enzymatic reactions for benchmarking the overall performance of the system. The measured results from the urea-urease reaction demonstrate that the system can detect urea in concentrations as low as 25 µM, which translates to a change of 27 mpH, according to our initial pH characterisation measurements. The attained accuracy and resolution of our system as well as its low-cost manufacturability, high processing speed and portability make it a competitive solution for applications requiring rapid and accurate results at remote locations; a necessity for Point-of-Care (POC) diagnostic platforms.

Original languageEnglish
Article number2000
JournalSensors (Switzerland)
Volume17
Issue number9
DOIs
Publication statusPublished - 1 Sept 2017

Keywords / Materials (for Non-textual outputs)

  • Analog-to-digital conversion
  • Biosensor
  • Nanoribbon
  • PH sensing
  • Point-of-Care diagnostics
  • Switched capacitor
  • TFT
  • Urea-urease reaction

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