A syntactic model to design and verify synthetic genetic constructs derived from standard biological parts

Yizhi Cai, Brian Hartnett, Claes Gustafsson, Jean Peccoud

Research output: Contribution to journalArticlepeer-review

Abstract

The sequence of artificial genetic constructs is composed of multiple functional fragments, or genetic parts, involved in different molecular steps of gene expression mechanisms. Biologists have deciphered structural rules that the design of genetic constructs needs to follow in order to ensure a successful completion of the gene expression process, but these rules have not been formalized, making it challenging for non-specialists to benefit from the recent progress in gene synthesis.
Original languageEnglish
Pages (from-to)2760-7
Number of pages8
JournalBioinformatics
Volume23
Issue number20
DOIs
Publication statusPublished - 15 Oct 2007

Keywords

  • Chromosome Mapping
  • Computer Simulation
  • DNA
  • Genetic Code
  • Genetic Engineering
  • Genomic Islands
  • Models, Genetic

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