A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins

Daniel J Antoine; Helena Erlandsson Harris; Ulf Andersson; Kevin J Tracey; Marco E Bianchi

doi:10.2119/molmed.2014.00022

A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins

Daniel J Antoine, Helena Erlandsson Harris, Ulf Andersson, Kevin J Tracey, Marco E Bianchi

Research output: Contribution to journal › Article › peer-review

Abstract

High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines of HMGB1 endow it with mutually exclusive activities, such as inducing chemotaxis or the transcription of cytokines and chemokines, via the interaction with different receptors. The different HMGB1 redox forms can be identified by mass spectrometry in body fluids of patients and may hold promise as biomarkers. We propose here a systematic nomenclature of the different redox forms of HMGB1 and related proteins, to replace the conflicting names used so far by different laboratories.

Original language	English
Pages (from-to)	135-7
Number of pages	3
Journal	Molecular Medicine
Volume	20
DOIs	https://doi.org/10.2119/molmed.2014.00022
Publication status	Published - 24 Mar 2014

Keywords / Materials (for Non-textual outputs)

Binding Sites
Biomarkers
Cysteine
HMGB1 Protein
Humans
Oxidation-Reduction
Terminology as Topic
Journal Article

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10.2119/molmed.2014.00022

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abstract = "High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines of HMGB1 endow it with mutually exclusive activities, such as inducing chemotaxis or the transcription of cytokines and chemokines, via the interaction with different receptors. The different HMGB1 redox forms can be identified by mass spectrometry in body fluids of patients and may hold promise as biomarkers. We propose here a systematic nomenclature of the different redox forms of HMGB1 and related proteins, to replace the conflicting names used so far by different laboratories.",

keywords = "Binding Sites, Biomarkers, Cysteine, HMGB1 Protein, Humans, Oxidation-Reduction, Terminology as Topic, Journal Article",

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AU - Antoine, Daniel J

AU - Harris, Helena Erlandsson

AU - Andersson, Ulf

AU - Tracey, Kevin J

AU - Bianchi, Marco E

PY - 2014/3/24

Y1 - 2014/3/24

N2 - High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines of HMGB1 endow it with mutually exclusive activities, such as inducing chemotaxis or the transcription of cytokines and chemokines, via the interaction with different receptors. The different HMGB1 redox forms can be identified by mass spectrometry in body fluids of patients and may hold promise as biomarkers. We propose here a systematic nomenclature of the different redox forms of HMGB1 and related proteins, to replace the conflicting names used so far by different laboratories.

AB - High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines of HMGB1 endow it with mutually exclusive activities, such as inducing chemotaxis or the transcription of cytokines and chemokines, via the interaction with different receptors. The different HMGB1 redox forms can be identified by mass spectrometry in body fluids of patients and may hold promise as biomarkers. We propose here a systematic nomenclature of the different redox forms of HMGB1 and related proteins, to replace the conflicting names used so far by different laboratories.

KW - Binding Sites

KW - Biomarkers

KW - Cysteine

KW - HMGB1 Protein

KW - Humans

KW - Oxidation-Reduction

KW - Terminology as Topic

KW - Journal Article

U2 - 10.2119/molmed.2014.00022

DO - 10.2119/molmed.2014.00022

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SN - 1076-1551

VL - 20

SP - 135

EP - 137

JO - Molecular Medicine

JF - Molecular Medicine

ER -

A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins

Abstract

Keywords / Materials (for Non-textual outputs)

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