A systematic review and meta-analysis of retinal nerve fiber layer change in dementia, using optical coherence tomography

Kelsey L. Thomson, Jing Ming Yeo, Briony Waddell, James R. Cameron, Suvankar Pal

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction:
Retinal nerve fiber layer (RNFL) thinning, assessed by optical coherence tomography (OCT), has recently been reported in various dementias.
Methods:
We conducted a systematic review and meta-analysis to investigate the diagnostic utility of RNFL thickness measurement using OCT in dementia (including Alzheimer’s disease [AD] and mild cognitive impairment [MCI]) compared with healthy controls (HC).
Results:
Seventeen studies comparing AD with HC (702 AD eyes and 790 HC eyes) were included, demonstrating a significant reduction in mean RNFL thickness in AD (weighted mean difference [WMD] 12.44, 95% confidence interval or CI [216.64, 28.25], P ,.0001). Five studies comparing MCI and HC (214 MCI eyes and 421 HC eyes) were included demonstrating a significant reduction in mean RNFL thickness in MCI (WMD 28.23, 95% CI [214.00, 22.45], P 5.005). No relevant
studies were identified for other dementias.
Discussion:
OCT measurement of RNFL thickness appears diagnostically useful in discriminating between AD, or MCI, and HC.
Original languageEnglish
Pages (from-to)136-143
Number of pages8
JournalAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume1
Issue number2
Early online date23 Apr 2015
DOIs
Publication statusPublished - 6 May 2015

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