A Systems Pathway View of Cytomegalovirus Infection

Peter Ghazal, Alexander Mazein, Steven Watterson, Ana Angulo, Kai A Kropp

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract / Description of output

This chapter discusses the use of systems biology towards understanding the combinatorially complex set of molecular interactions that underpin the infection process by CMV. A hallmark of systems biology is the elucidation of pathways rather than single gene or protein activities. This generally involves the use of bioinformatics and computational modelling to analyse unbiased high-throughput data such as those derived from whole genome sequencing, genome-wide transcriptomics, proteomics and metabolomics. The emerging studies in the area of CMV systems biology have to date underscored the requirement for host dependencies on transcription factor networks, cell signalling, metabolism and cellular trafficking. Here we consider at the systems pathway level the importance of host dependency and host protection pathways in regulating the CMV transcription–replication cycle.
Original languageEnglish
Title of host publicationCytomegaloviruses
EditorsMatthias Reddehase
PublisherCaister Academic Press
Pages108 - 123
Number of pages15
EditionApril 2013
ISBN (Print)978-1-908230-18-8
Publication statusPublished - Apr 2013


Dive into the research topics of 'A Systems Pathway View of Cytomegalovirus Infection'. Together they form a unique fingerprint.

Cite this