A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation

John Parkinson; James D Wasmuth; Gustavo Salinas; Cristiano V Bizarro; Chris Sanford; Matthew Berriman; Henrique B Ferreira; Arnaldo Zaha; Mark L Blaxter; Rick M Maizels; Cecilia Fernández

doi:10.1371/journal.pntd.0001897

A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation

John Parkinson, James D Wasmuth, Gustavo Salinas, Cristiano V Bizarro, Chris Sanford, Matthew Berriman, Henrique B Ferreira, Arnaldo Zaha, Mark L Blaxter, Rick M Maizels, Cecilia Fernández

Research output: Contribution to journal › Article › peer-review

Abstract

The cestode Echinococcus granulosus--the agent of cystic echinococcosis, a zoonosis affecting humans and domestic animals worldwide--is an excellent model for the study of host-parasite cross-talk that interfaces with two mammalian hosts. To develop the molecular analysis of these interactions, we carried out an EST survey of E. granulosus larval stages. We report the salient features of this study with a focus on genes reflecting physiological adaptations of different parasite stages.

Original language	English
Article number	e1897
Journal	PLoS Neglected Tropical Diseases
Volume	6
Issue number	11
DOIs	https://doi.org/10.1371/journal.pntd.0001897
Publication status	Published - 2012

Keywords

Animals
Larva
Molecular Sequence Data
Echinococcus granulosus
Sequence Analysis, DNA
Transcriptome
Expressed Sequence Tags

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10.1371/journal.pntd.0001897

A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation
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Parkinson, J., Wasmuth, J. D., Salinas, G., Bizarro, C. V., Sanford, C., Berriman, M., Ferreira, H. B., Zaha, A., Blaxter, M. L., Maizels, R. M., & Fernández, C. (2012). A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation. PLoS Neglected Tropical Diseases, 6(11), [e1897]. https://doi.org/10.1371/journal.pntd.0001897

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Parkinson, J, Wasmuth, JD, Salinas, G, Bizarro, CV, Sanford, C, Berriman, M, Ferreira, HB, Zaha, A, Blaxter, ML, Maizels, RM & Fernández, C 2012, 'A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation', PLoS Neglected Tropical Diseases, vol. 6, no. 11, e1897. https://doi.org/10.1371/journal.pntd.0001897

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AU - Parkinson, John

AU - Wasmuth, James D

AU - Salinas, Gustavo

AU - Bizarro, Cristiano V

AU - Sanford, Chris

AU - Berriman, Matthew

AU - Ferreira, Henrique B

AU - Zaha, Arnaldo

AU - Blaxter, Mark L

AU - Maizels, Rick M

AU - Fernández, Cecilia

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AB - The cestode Echinococcus granulosus--the agent of cystic echinococcosis, a zoonosis affecting humans and domestic animals worldwide--is an excellent model for the study of host-parasite cross-talk that interfaces with two mammalian hosts. To develop the molecular analysis of these interactions, we carried out an EST survey of E. granulosus larval stages. We report the salient features of this study with a focus on genes reflecting physiological adaptations of different parasite stages.

KW - Animals

KW - Larva

KW - Molecular Sequence Data

KW - Echinococcus granulosus

KW - Sequence Analysis, DNA

KW - Transcriptome

KW - Expressed Sequence Tags

U2 - 10.1371/journal.pntd.0001897

DO - 10.1371/journal.pntd.0001897

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SN - 1935-2727

IS - 11

M1 - e1897

ER -

A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation

Abstract

Keywords

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