A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation

John Parkinson, James D Wasmuth, Gustavo Salinas, Cristiano V Bizarro, Chris Sanford, Matthew Berriman, Henrique B Ferreira, Arnaldo Zaha, Mark L Blaxter, Rick M Maizels, Cecilia Fernández

Research output: Contribution to journalArticlepeer-review

Abstract

The cestode Echinococcus granulosus--the agent of cystic echinococcosis, a zoonosis affecting humans and domestic animals worldwide--is an excellent model for the study of host-parasite cross-talk that interfaces with two mammalian hosts. To develop the molecular analysis of these interactions, we carried out an EST survey of E. granulosus larval stages. We report the salient features of this study with a focus on genes reflecting physiological adaptations of different parasite stages.
Original languageEnglish
Article numbere1897
JournalPLoS Neglected Tropical Diseases
Volume6
Issue number11
DOIs
Publication statusPublished - 2012

Keywords

  • Animals
  • Larva
  • Molecular Sequence Data
  • Echinococcus granulosus
  • Sequence Analysis, DNA
  • Transcriptome
  • Expressed Sequence Tags

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